Technology Process of (R)-4-Benzyloxy-5-((4R,5R)-4,5-dimethyl-[1,3]dioxolan-2-yl)-1-methoxy-5-methyl-hexan-2-one
There total 6 articles about (R)-4-Benzyloxy-5-((4R,5R)-4,5-dimethyl-[1,3]dioxolan-2-yl)-1-methoxy-5-methyl-hexan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: p-TsOH*H2O / benzene / 8 h / Heating
2: 64 percent / PCC, NaOAc / CH2Cl2 / 12 h / Ambient temperature
3: 2.) Jones reagent / 1.) ether, 12 h at r.t.; 2.) acetone, 30 min at 0 deg C
4: 1.) LiAlH4; 2.) t-AmONa / 1.) ether, toluene, 2 h at -123 deg C; 2.) DMSO, 2 h at r.t.
5: 99 percent / mCPBA / CH2Cl2 / 12 h / Ambient temperature
6: 1.) NaOMe; 2.) Collins reagent / 1.) benzene, 2 d at r.t.; 2.) CH2Cl2, 2 h at r.t.
With
lithium aluminium tetrahydride; jones reagent; Collins oxidation agent; sodium methylate; sodium acetate; sodium tert-pentoxide; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate;
In
dichloromethane; benzene;
DOI:10.1016/0040-4020(84)80017-4
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) LiAlH4; 2.) t-AmONa / 1.) ether, toluene, 2 h at -123 deg C; 2.) DMSO, 2 h at r.t.
2: 99 percent / mCPBA / CH2Cl2 / 12 h / Ambient temperature
3: 1.) NaOMe; 2.) Collins reagent / 1.) benzene, 2 d at r.t.; 2.) CH2Cl2, 2 h at r.t.
With
lithium aluminium tetrahydride; Collins oxidation agent; sodium methylate; sodium tert-pentoxide; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
DOI:10.1016/0040-4020(84)80017-4
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 64 percent / PCC, NaOAc / CH2Cl2 / 12 h / Ambient temperature
2: 2.) Jones reagent / 1.) ether, 12 h at r.t.; 2.) acetone, 30 min at 0 deg C
3: 1.) LiAlH4; 2.) t-AmONa / 1.) ether, toluene, 2 h at -123 deg C; 2.) DMSO, 2 h at r.t.
4: 99 percent / mCPBA / CH2Cl2 / 12 h / Ambient temperature
5: 1.) NaOMe; 2.) Collins reagent / 1.) benzene, 2 d at r.t.; 2.) CH2Cl2, 2 h at r.t.
With
lithium aluminium tetrahydride; jones reagent; Collins oxidation agent; sodium methylate; sodium acetate; sodium tert-pentoxide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate;
In
dichloromethane;
DOI:10.1016/0040-4020(84)80017-4
