6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid

Base Information

Chemical Name:6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid
CAS No.:860264-47-7
Molecular Formula:C₅₂H₆₀N₂O₁₀
Molecular Weight:873.056
Hs Code.:

6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid

Synonyms:6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid

There total 9 articles about 6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 860264-43-3
6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-1-O,2-N-isopropylidene-L-erythro-L-galacto-undecitol

: 860264-47-7
6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid

Guidance literature:: With jones reagent; In acetone; at 0 - 20 ℃; for 3.5h;
DOI:10.1021/jo050494o

Reference yield:

: 860264-48-8
methyl 6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconate

: 860264-47-7
6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃; for 14h;
DOI:10.1021/jo050494o

Reference yield:

: (2S,3S,4R,5S,6S)-2-Allyl-3,4,5-tris-benzyloxy-6-benzyloxymethyl-piperidine

: 860264-47-7
6,10-anhydro-7,8,9,11-tetra-O-benzyl-6-N-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-2,3,4,5,6-pentadeoxy-L-erythro-L-galacto-undeconic acid

Guidance literature:: Multi-step reaction with 4 steps

1: NaHCO₃ / ethanol; H₂O / 1 h / 0 °C

2: 50 percent / Grubbs second generation catalyst / CH₂Cl₂ / 18 h / 40 °C

3: 82 percent / toluene-p-sulfonylhydrazide; aq. AcONa / 1,2-dimethoxy-ethane / 85 °C

4: Jones reagent / acetone / 3.5 h / 0 - 20 °C

With jones reagent; sodium acetate; sodium hydrogencarbonate; toluene-4-sulfonic acid hydrazide; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jo050494o