Technology Process of tert-butyl{[3-iodo-5-isobutyl-2,6-bis(methoxymethoxy)benzyl]oxy}dimethylsilane
There total 7 articles about tert-butyl{[3-iodo-5-isobutyl-2,6-bis(methoxymethoxy)benzyl]oxy}dimethylsilane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
tert-butyl{[3-isobutyl-2,6-bis(methoxymethoxy)benzyl]oxy}dimethylsilane;
With
sec.-butyllithium;
In
tetrahydrofuran; hexane; cyclohexane;
at -78 ℃;
for 2h;
With
N-iodo-succinimide;
In
tetrahydrofuran; hexane; cyclohexane;
at -78 ℃;
for 3h;
DOI:10.1021/jo061104g
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 93 percent / H2 / Pd/C / ethanol / 24 h / 3102.89 Torr
2.1: n-BuLi; TMEDA / diethyl ether; hexane / 2 h / 0 °C
2.2: 86 percent / diethyl ether; hexane / 3 h / 20 °C
3.1: 95 percent / NaBH4 / tetrahydrofuran / 1.5 h / 20 °C
4.1: 85 percent / imidazole / dimethylformamide / 36 h / 20 °C
5.1: sec-BuLi / tetrahydrofuran; cyclohexane; hexane / 2 h / -78 °C
5.2: 55 percent / N-iodosuccinimide / tetrahydrofuran; cyclohexane; hexane / 3 h / -78 °C
With
1H-imidazole; sodium tetrahydroborate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; sec.-butyllithium;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; cyclohexane; N,N-dimethyl-formamide;
DOI:10.1021/jo061104g
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 94 percent / tetrahydrofuran; hexane / 4 h / 20 °C
2.1: 93 percent / H2 / Pd/C / ethanol / 24 h / 3102.89 Torr
3.1: n-BuLi; TMEDA / diethyl ether; hexane / 2 h / 0 °C
3.2: 86 percent / diethyl ether; hexane / 3 h / 20 °C
4.1: 95 percent / NaBH4 / tetrahydrofuran / 1.5 h / 20 °C
5.1: 85 percent / imidazole / dimethylformamide / 36 h / 20 °C
6.1: sec-BuLi / tetrahydrofuran; cyclohexane; hexane / 2 h / -78 °C
6.2: 55 percent / N-iodosuccinimide / tetrahydrofuran; cyclohexane; hexane / 3 h / -78 °C
With
1H-imidazole; sodium tetrahydroborate; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; sec.-butyllithium;
palladium on activated charcoal;
In
tetrahydrofuran; diethyl ether; ethanol; hexane; cyclohexane; N,N-dimethyl-formamide;
1.1: Wittig reaction;
DOI:10.1021/jo061104g
![tert-butyl{[3-isobutyl-2,6-bis(methoxymethoxy)benzyl]oxy}dimethylsilane](/Databaselist/images/loading.webp)
