(2S)-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide

Base Information

Chemical Name:(2S)-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide
CAS No.:1240523-66-3
Molecular Formula:C₂₇H₂₅ClN₄O
Molecular Weight:456.975
Hs Code.:

Synonyms:(2S)-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide

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Chemical Property of (2S)-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide

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Technology Process of (2S)-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide

There total 4 articles about (2S)-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1121-60-4
pyridine-2-carbaldehyde

: 1240523-64-1
(2S)-2-amino-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenylpropanamide

: 1240523-66-3
(2S)-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide

Guidance literature:: pyridine-2-carbaldehyde; (2S)-2-amino-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenylpropanamide; With acetic acid; trimethyl orthoformate; for 0.5h;

With sodium tris(acetoxy)borohydride; for 1h;

With hydrogenchloride; water;

Reference yield:

: 96558-78-0
3-bromo-5-chlorophenylamine

: 1240523-66-3
(2S)-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 14 h

2.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 8 h / 85 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h

4.1: acetic acid; trimethyl orthoformate / 0.5 h

4.2: 1 h

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; triethylamine; cesium fluoride; trifluoroacetic acid; trimethyl orthoformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1240523-63-0
(S)-tert-butyl 1-(3-bromo-5-chlorophenylamino)-1-oxo-3-phenylpropan-2-ylcarbamate

: 1240523-66-3
(2S)-N-(3-chloro-5-(2-methylpyridin-4-yl)phenyl)-3-phenyl-2-(pyridin-2-ylmethylamino)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 8 h / 85 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h

3.1: acetic acid; trimethyl orthoformate / 0.5 h

3.2: 1 h

With acetic acid; cesium fluoride; trifluoroacetic acid; trimethyl orthoformate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane;