2t-carboxymethyl-1,3-dimethyl-cyclohexane-1r,3c-dicarboxylic acid

Base Information

• Chemical Name: 2t-carboxymethyl-1,3-dimethyl-cyclohexane-1r,3c-dicarboxylic acid
• CAS No.: 4884-89-3
• Molecular Formula: C₁₂H₁₈O₆
• Molecular Weight: 258.271
• Mol file: 4884-89-3.mol

Synonyms:2t-carboxymethyl-1,3-dimethyl-cyclohexane-1r,3c-dicarboxylic acid

Chemical Property of 2t-carboxymethyl-1,3-dimethyl-cyclohexane-1r,3c-dicarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2t-carboxymethyl-1,3-dimethyl-cyclohexane-1r,3c-dicarboxylic acid

There total 12 articles about 2t-carboxymethyl-1,3-dimethyl-cyclohexane-1r,3c-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-1,7-heptanedioic acid dimethyl ester (33658-48-9) → <1,3-Dimethyl-1,3-dicarboxy-cyclohexyl-(2)-essigsaeure (4884-89-3,91766-38-0)

Guidance literature:

Multi-step reaction with 9 steps

1: NaH / benzene / Heating

2: (i) Na, benzene, (ii) /BRN= 969135/

3: (i) Zn, I₂, benzene, (ii) SOCl₂, Py, Et₂O

4: aq. KOH / methanol / Heating

5: (i) (COCl)2, benzene, (ii) /BRN= 102415/, Et₂O, (iii) /BRN= 1098229/, Ag₂O

6: aq. KOH / methanol / Heating

7: P₂O₅ / benzene / Heating

8: H₂ / PtO₂ / ethanol

9: (i) HCO₂Et, NaOEt, benzene, (ii) H₂O₂, aq. NaOH, EtOH, (iii) aq. KOH, MeOH

With potassium hydroxide; hydrogen; phosphorus pentoxide; sodium hydride; platinum(IV) oxide; In methanol; ethanol; benzene;

DOI:10.1016/S0040-4020(01)93172-2

Reference yield:

ethyl 1-methyl-2-oxocyclohexancarboxylate (66088-37-7,5453-94-1) → <1,3-Dimethyl-1,3-dicarboxy-cyclohexyl-(2)-essigsaeure (4884-89-3,91766-38-0)

Guidance literature:

Multi-step reaction with 10 steps

1: (i) NaOEt, EtOH, (ii) aq. KOH, MeOH, (iii) /BRN= 1098229/, H₂SO₄

2: NaH / benzene / Heating

3: (i) Na, benzene, (ii) /BRN= 969135/

4: (i) Zn, I₂, benzene, (ii) SOCl₂, Py, Et₂O

5: aq. KOH / methanol / Heating

6: (i) (COCl)2, benzene, (ii) /BRN= 102415/, Et₂O, (iii) /BRN= 1098229/, Ag₂O

7: aq. KOH / methanol / Heating

8: P₂O₅ / benzene / Heating

9: H₂ / PtO₂ / ethanol

10: (i) HCO₂Et, NaOEt, benzene, (ii) H₂O₂, aq. NaOH, EtOH, (iii) aq. KOH, MeOH

With potassium hydroxide; hydrogen; phosphorus pentoxide; sodium hydride; platinum(IV) oxide; In methanol; ethanol; benzene;

DOI:10.1016/S0040-4020(01)93172-2

Reference yield:

(1,3-Dimethyl-3-methoxycarbonyl-cyclohexen-(1)-yl)-propionsaeure-methylester (106591-27-9) → <1,3-Dimethyl-1,3-dicarboxy-cyclohexyl-(2)-essigsaeure (4884-89-3,91766-38-0)

Guidance literature:

Multi-step reaction with 4 steps

1: aq. KOH / methanol / Heating

2: P₂O₅ / benzene / Heating

3: H₂ / PtO₂ / ethanol

4: (i) HCO₂Et, NaOEt, benzene, (ii) H₂O₂, aq. NaOH, EtOH, (iii) aq. KOH, MeOH

With potassium hydroxide; hydrogen; phosphorus pentoxide; platinum(IV) oxide; In methanol; ethanol; benzene;

DOI:10.1016/S0040-4020(01)93172-2

upstream raw materials:

abietic acid

2-methyl-1,7-heptanedioic acid dimethyl ester

ethyl 1-methyl-2-oxocyclohexancarboxylate

methyl 3-methyl-2-oxocyclohexane-1-carboxylate

Downstream raw materials:

1,2,3-trimethylbenzene