2-Methylpimelic acid dimethyl ester

Base Information

• Chemical Name: 2-Methylpimelic acid dimethyl ester
• CAS No.: 33658-48-9
• Molecular Formula: C10H18O4
• Molecular Weight: 202.251
• Hs Code.: 2917190090
• Mol file: 33658-48-9.mol

Synonyms:2-methyl-1,7-heptanedioic acid dimethyl ester;Dimethyl-2-methylheptandicarboxylat;2-methylpimelic acid dimethyl ester;dimethyl 2-methylpimelate;2-Methyl-pimelinsaeure-dimethylester;Dimethyl 2-methylheptane-1,7-dioate;

Chemical Property of 2-Methylpimelic acid dimethyl ester

Chemical Property:

• Boiling Point: 98-100 °C(Press: 1.0 Torr)
• PSA: 52.60000
• Density: 1.006±0.06 g/cm3(Predicted)
• LogP: 1.52890
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Dimethyl2-methylheptanedioate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methylpimelic acid dimethyl ester

There total 1 articles about 2-Methylpimelic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + carbonic acid dimethyl ester (616-38-6) → 2-(1-cyclohexenyl)cyclohexanone (1502-22-3) + dimethyl 1,7-heptanedioate (1732-08-7) + 2-methyl-1,7-heptanedioic acid dimethyl ester (33658-48-9)

Guidance literature:

With 2-ethyl-1,3-dimethylimidazolium methyl carbonate; at 200 ℃; for 9h;

DOI:10.1016/j.catcom.2013.11.013

Reference yield:

2-methyl-1,7-heptanedioic acid dimethyl ester (33658-48-9) → <1,3-Dimethyl-1,3-dicarboxy-cyclohexyl-(2)-essigsaeure (4884-89-3,91766-38-0)

Guidance literature:

Multi-step reaction with 9 steps

1: NaH / benzene / Heating

2: (i) Na, benzene, (ii) /BRN= 969135/

3: (i) Zn, I₂, benzene, (ii) SOCl₂, Py, Et₂O

4: aq. KOH / methanol / Heating

5: (i) (COCl)2, benzene, (ii) /BRN= 102415/, Et₂O, (iii) /BRN= 1098229/, Ag₂O

6: aq. KOH / methanol / Heating

7: P₂O₅ / benzene / Heating

8: H₂ / PtO₂ / ethanol

9: (i) HCO₂Et, NaOEt, benzene, (ii) H₂O₂, aq. NaOH, EtOH, (iii) aq. KOH, MeOH

With potassium hydroxide; hydrogen; phosphorus pentoxide; sodium hydride; platinum(IV) oxide; In methanol; ethanol; benzene;

DOI:10.1016/S0040-4020(01)93172-2

Reference yield:

2-methyl-1,7-heptanedioic acid dimethyl ester (33658-48-9) → methyl 3-methyl-2-oxocyclohexane-1-carboxylate (59416-90-9)

Guidance literature:

With sodium hydride; In benzene; Heating;

DOI:10.1016/S0040-4020(01)93172-2

upstream raw materials:

cyclohexanone

carbonic acid dimethyl ester

Downstream raw materials:

methyl 3-methyl-2-oxocyclohexane-1-carboxylate

<1,3-Dimethyl-1,3-dicarboxy-cyclohexyl-(2)-essigsaeure