4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile

Base Information

Chemical Name:4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile
CAS No.:1259521-29-3
Molecular Formula:C₂₃H₁₉FN₆O₂S
Molecular Weight:462.507
Hs Code.:

Synonyms:4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile

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Chemical Property of 4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile

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Technology Process of 4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile

There total 13 articles about 4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1259521-38-4
1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethanamine

: 60025-09-4
4-amino-6-chloropyrimidine-5-carbonitrile

: 1259521-29-3
4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 130 ℃;

Reference yield:

: 371-40-4
4-fluoroaniline

: 1259521-29-3
4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 11 steps

1: pyridine / 16 h / 130 °C

2: lithium hydroxide / tetrahydrofuran / 2 h

3: polyphosphoric acid / 2 h / 130 °C

4: trichlorophosphate / 2 h / 100 °C

5: potassium carbonate; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex / tetrahydrofuran / 6 h / Reflux

6: N,N-dimethyl-formamide / 0.5 h / 60 °C

7: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

8: N,N-dimethyl-formamide / 16 h / 60 °C

9: oxone / tetrahydrofuran; water / 16 h / 20 °C

10: hydrazine / ethanol / 0.5 h / 60 °C

11: butan-1-ol / 16 h / 100 °C

With pyridine; N-Bromosuccinimide; 1,1'-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex; potassium carbonate; lithium hydroxide; hydrazine; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.bmcl.2015.01.001

Reference yield:

: 1259521-34-0
4-chloro-2-ethyl-6-fluoro-3-phenylquinoline

: 1259521-29-3
4-amino-6-(1-(6-fluoro-4-(methylsulfonyl)-3-phenylquinolin-2-yl)ethylamino)-pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: N,N-dimethyl-formamide / 0.5 h / 60 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 3 h / Reflux

3: N,N-dimethyl-formamide / 16 h / 60 °C

4: oxone / tetrahydrofuran; water / 16 h / 20 °C

5: hydrazine / ethanol / 0.5 h / 60 °C

6: butan-1-ol / 16 h / 100 °C

With N-Bromosuccinimide; hydrazine; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; water; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1016/j.bmcl.2015.01.001