(S)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol

Base Information

• Chemical Name: (S)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol
• CAS No.: 135145-21-0
• Molecular Formula: C₁₅H₁₅ClO₂S
• Molecular Weight: 294.802
• Mol file: 135145-21-0.mol

Synonyms:(S)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol

Chemical Property of (S)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol

There total 3 articles about (S)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chlorophenylmagnesium bromide (36692-27-0) → (S)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol (135145-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / diethyl ether / 0 °C

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 15 min, 2.) -78 deg C, 30 min

With lithium diisopropyl amide; In diethyl ether;

DOI:10.1021/jo00019a053

Reference yield:

(-)-menthyl p-toluenesulfinate (1517-82-4) → (S)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol (135145-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / diethyl ether / 0 °C

2: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 15 min, 2.) -78 deg C, 30 min

With lithium diisopropyl amide; In diethyl ether;

DOI:10.1021/jo00019a053

Reference yield:

(R)-(+)-2-chlorophenyl 4-methylphenyl sulfoxide (20268-16-0) + acetaldehyde (75-07-0,9002-91-9) → (S)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol (135145-21-0) + (R)-1-[3-Chloro-2-((S)-toluene-4-sulfinyl)-phenyl]-ethanol (135145-20-9)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, -78 deg C, 15 min, 2.) -78 deg C, 30 min;

DOI:10.1021/jo00019a053

upstream raw materials:

(R)-(+)-2-chlorophenyl 4-methylphenyl sulfoxide

acetaldehyde

2-chlorophenylmagnesium bromide

(-)-menthyl p-toluenesulfinate

Downstream raw materials:

(S)-1-(m-chlorophenyl)ethanol

(S)-1-(ethylsulfinyl)-4-methylbenzene