(2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

Base Information

• Chemical Name: (2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone
• CAS No.: 204583-33-5
• Molecular Formula: C₁₄H₁₇FO₃
• Molecular Weight: 252.286
• Mol file: 204583-33-5.mol

Synonyms:(2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

Chemical Property of (2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone

There total 2 articles about (2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

o-fluorobromobenzene (1072-85-1) + 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine (135270-08-5) → (2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (204583-33-5)

Guidance literature:

With ethidium Bromide; magnesium; In tetrahydrofuran; for 2h;

DOI:10.1248/cpb.43.432

Reference yield:

o-fluorobromobenzene (1072-85-1) + ethyl bromide (74-96-4) + ammonium chloride + 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine (135270-08-5) → (2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (204583-33-5)

Guidance literature:

With magnesium; In tetrahydrofuran; water;

Reference yield:

chloromethylisopropoxydimethylsilane (18171-11-4) + (2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone (204583-33-5) → C20H33FO4Si (917246-43-6)

Guidance literature:

chloromethylisopropoxydimethylsilane; With magnesium; In diethyl ether;

(2R)-2'-fluoro-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propiophenone; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; Further stages.;

DOI:10.1016/j.jfluchem.2005.12.008

upstream raw materials:

o-fluorobromobenzene

4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine

ethyl bromide

Downstream raw materials:

C₂₀H₃₃FO₄Si