6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

Base Information

Chemical Name:6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol
CAS No.:472979-46-7
Molecular Formula:C₂₄H₄₂O₄Si
Molecular Weight:422.681
Hs Code.:

Synonyms:6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

Suppliers and Price of 6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

There total 9 articles about 6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 472980-12-4
6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-one

: 6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

: 472979-46-7
6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

: 6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-octan-4-one

Guidance literature:: With dimethylsulfide borane complex; (S)-Me-CBS reagent; In tetrahydrofuran; toluene; at -30 ℃; for 3h;
DOI:10.1016/S0040-4020(03)00916-5

Reference yield:

: 590-15-8
trans-2-propenyl bromide

: 472979-36-5
(3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal

: 6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

: 472979-46-7
6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

Guidance literature:: With tert.-butyl lithium; In tetrahydrofuran; diethyl ether; at -95 ℃;
DOI:10.1016/S0040-4020(03)00916-5

Reference yield:

: 128461-65-4
3-(p-methoxybenzyloxy)propanal

: 472979-46-7
6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1: N-Tos-D-valine; BH₃*THF; K₂CO₃ / CH₂Cl₂; methanol

2: 99 percent / 2,6-lutidine; DMAP / CH₂Cl₂ / 20 °C

3: 94 percent / DIBAH / toluene / -78 °C

4: 83 percent / Dess-Martin periodinane / CH₂Cl₂ / 0 - 20 °C

5: t-BuLi / diethyl ether; tetrahydrofuran / -95 °C

With 2,6-dimethylpyridine; dmap; borane-THF; N-((4-methylphenyl)sulfonyl)-D-valine; tert.-butyl lithium; diisobutylaluminium hydride; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; 4: Dess-Martin oxidation reaction;
DOI:10.1021/ol026468j