(3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal

Base Information

• Chemical Name: (3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal
• CAS No.: 472979-36-5
• Molecular Formula: C₂₁H₃₆O₄Si
• Molecular Weight: 380.6
• Mol file: 472979-36-5.mol

Synonyms:(3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal

Chemical Property of (3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal

There total 16 articles about (3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol (472979-90-1) → (3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal (472979-36-5)

Guidance literature:

3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol; With dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 - -10 ℃; for 0.0833333h; Inert atmosphere;

With sulfur trioxide pyridine complex; In dichloromethane; at -20 - -10 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol303089w

Reference yield: 78.0%

(S)-tert-butyl ((1-(4-methoxybenzyloxy)-4,4-dimethylhex-5-en-3-yl)oxy)dimethylsilane (693221-74-8) → (3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal (472979-36-5)

Guidance literature:

(S)-tert-butyl ((1-(4-methoxybenzyloxy)-4,4-dimethylhex-5-en-3-yl)oxy)dimethylsilane; With ozone; In methanol; dichloromethane; at -78 ℃;

With dimethylsulfide; In methanol; dichloromethane; at 25 ℃;

DOI:10.1039/b508001k

Reference yield:

3-(p-methoxybenzyloxy)propanal (128461-65-4) → (3S)-3-tert-butyldimethylsilyloxy-5-p-methoxybenzyloxy-2,2-dimethylpentanal (472979-36-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / 2,6-lutidine

2: 78 percent / O₃

With 2,6-dimethylpyridine; ozone;

DOI:10.1016/j.tetlet.2003.11.087

upstream raw materials:

3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-2,2-dimethyl-pentan-1-ol

(S)-tert-butyl ((1-(4-methoxybenzyloxy)-4,4-dimethylhex-5-en-3-yl)oxy)dimethylsilane

1-hydroxy-4,4-dimethylhex-5-en-3-one

(3S)-4,4-dimethylhex-5-ene-1,3-diol

Downstream raw materials:

6-(tert-butyl-dimethyl-silanyloxy)-8-(4-methoxy-benzyloxy)-5,5-dimethyl-oct-2-en-4-ol

C₂₃H₄₀O₅Si

C₃₇H₅₉NO₇Si₂

C₂₇H₅₂O₅Si₂