4-(2-bromo-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

Base Information

Chemical Name:4-(2-bromo-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one
CAS No.:860782-81-6
Molecular Formula:C₂₅H₃₄BrNO₃Si
Molecular Weight:504.539
Hs Code.:

Synonyms:4-(2-bromo-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

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Chemical Property of 4-(2-bromo-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

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Technology Process of 4-(2-bromo-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

There total 6 articles about 4-(2-bromo-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 941672-61-3
4-(2-bromo-phenyl)-3-hydroxy-1-(4-methoxy-phenyl)-azetidin-2-one

: 13154-24-0
triisopropylsilyl chloride

: 860782-81-6
4-(2-bromo-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

Guidance literature:: With 1H-imidazole; In DMF (N,N-dimethyl-formamide);

Reference yield:

: 38018-60-9
(E)-N-(2-bromobenzylidene)-4-methoxyaniline

: 860782-81-6
4-(2-bromo-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: i-Pr₂NEt / CH₂Cl₂ / 12 h / -78 - 20 °C

2: lipase PS / aq. phosphate buffer; acetonitrile / 74 h / 20 °C / pH 7

3: aq. KOH / tetrahydrofuran / 0.25 h

4: imidazole / dimethylformamide / 8 h / 20 °C

With 1H-imidazole; potassium hydroxide; Lipase PS; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; phosphate buffer; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm061071x

Reference yield:

: 104-94-9
4-methoxy-aniline

: 860782-81-6
4-(2-bromo-phenyl)-1-(4-methoxy-phenyl)-3-triisopropylsilanyloxy-azetidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: MgSO₄ / CH₂Cl₂ / 12 h

2: i-Pr₂NEt / CH₂Cl₂ / 12 h / -78 - 20 °C

3: lipase PS / aq. phosphate buffer; acetonitrile / 74 h / 20 °C / pH 7

4: aq. KOH / tetrahydrofuran / 0.25 h

5: imidazole / dimethylformamide / 8 h / 20 °C

With 1H-imidazole; potassium hydroxide; Lipase PS; magnesium sulfate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; phosphate buffer; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm061071x