methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate

Base Information

Chemical Name:methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate
CAS No.:1164274-46-7
Molecular Formula:C₂₆H₄₁ClO₆Si₂
Molecular Weight:541.232
Hs Code.:

Synonyms:methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate

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Chemical Property of methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate

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Technology Process of methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate

There total 1 articles about methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1164274-45-6
methyl 2-(but-3-ynyl)-4,6-bis(tert-butyldimethylsilyloxy)-3-chlorobenzoate

: 79-22-1
methyl chloroformate

: 1164274-46-7
methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate

Guidance literature:: methyl 2-(but-3-ynyl)-4,6-bis(tert-butyldimethylsilyloxy)-3-chlorobenzoate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.0833333h;

methyl chloroformate; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1021/jo900278g

Reference yield: 85.0%

: 4214-73-7
6-aminonicotinonitrile

: 1164274-46-7
methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate

: 1164274-47-8
methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-(5-cyanopyridin-2-ylamino)-5-oxopent-3-ynyl)benzoate

Guidance literature:: 6-aminonicotinonitrile; With trimethylaluminum; In dichloromethane; toluene; at 0 - 25 ℃; for 1h;

methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate; With potassium carbonate; In dichloromethane; toluene; at 0 - 25 ℃;
DOI:10.1021/jo900278g

Reference yield: 81.0%

: 1164274-46-7
methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate

: 619-45-4
4-methoxycarbonyl aniline

: 1164274-50-3
methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-(4-(methoxycarbonyl)phenyl-amino)-5-oxopent-3-ynyl)benzoate

Guidance literature:: 4-methoxycarbonyl aniline; With trimethylaluminum; In dichloromethane; toluene; at 0 ℃; for 0.05h;

methyl 4,6-bis(tert-butyldimethylsilyloxy)-3-chloro-2-(5-methoxy-5-oxopent-3-ynyl)benzoate; With potassium carbonate; In dichloromethane; toluene; at 0 - 25 ℃;
DOI:10.1021/jo900278g