4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran

Base Information

Chemical Name:4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran
CAS No.:102625-14-9
Molecular Formula:C₂₃H₂₉NO₃
Molecular Weight:367.488
Hs Code.:

Synonyms:4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran

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Technology Process of 4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran

There total 10 articles about 4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 33797-51-2
eschenmoser's salt

: 102612-54-4
4-hydroxy-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran

: 102625-14-9
4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran

Guidance literature:: In dichloromethane; for 20h; Ambient temperature;
DOI:10.1021/jm00126a008

Reference yield:

: 2632-13-5
2-Bromo-4'-methoxyacetophenone

: 102625-14-9
4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / acetone / Heating

2: 37 percent / ZnI₂, NaCNBH₄ / 1,2-dichloro-ethane / 6 h / Heating

3: K₂CO₃

4: various solvent(s) / Heating

5: H₂ / Pd/C

6: 95 percent / CH₂Cl₂ / 20 h / Ambient temperature

With hydrogen; sodium cyanoborohydride; potassium carbonate; zinc(II) iodide; palladium on activated charcoal; In dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1021/jm00126a008

Reference yield:

: 699-83-2
2,6-dihydroxylacetophenone

: 102625-14-9
4-hydroxy-7-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methyl-5-propylbenzofuran

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / acetone / Heating

2: 37 percent / ZnI₂, NaCNBH₄ / 1,2-dichloro-ethane / 6 h / Heating

3: K₂CO₃

4: various solvent(s) / Heating

5: H₂ / Pd/C

6: 95 percent / CH₂Cl₂ / 20 h / Ambient temperature

With hydrogen; sodium cyanoborohydride; potassium carbonate; zinc(II) iodide; palladium on activated charcoal; In dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1021/jm00126a008