methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate

Base Information

Chemical Name:methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate
CAS No.:1234572-55-4
Molecular Formula:C₁₉H₁₆FN₇O₂S
Molecular Weight:425.446
Hs Code.:

Synonyms:methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate

Suppliers and Price of methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate

There total 5 articles about methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1234572-51-0
2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidine-4,5,6-triamine

: 4525-33-1
dimethyl dicarbonate

: 1234572-55-4
methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate

Guidance literature:: In 1-methyl-pyrrolidin-2-one; isopropyl alcohol; at 20 ℃; for 19h;

Reference yield:

: 66607-27-0
3-iodoindazole

: 1234572-55-4
methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / copper(l) iodide / isopropyl alcohol; ethylene glycol / 20 h / 130 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide; toluene / 17 h / 90 °C / Inert atmosphere

3: hydrogen; pyridine / palladium 10% on activated carbon / 17 h / 20 °C / 2625.26 Torr

4: isopropyl alcohol; 1-methyl-pyrrolidin-2-one / 19 h / 20 °C

With pyridine; hydrogen; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; XPhos; In 1-methyl-pyrrolidin-2-one; ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

Reference yield:

: 2557-78-0
2-fluorothiophenol

: 1234572-55-4
methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / copper(l) iodide / isopropyl alcohol; ethylene glycol / 20 h / 130 °C

2: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide; toluene / 17 h / 90 °C / Inert atmosphere

3: hydrogen; pyridine / palladium 10% on activated carbon / 17 h / 20 °C / 2625.26 Torr

4: isopropyl alcohol; 1-methyl-pyrrolidin-2-one / 19 h / 20 °C

With pyridine; hydrogen; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; XPhos; In 1-methyl-pyrrolidin-2-one; ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;