Methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)(2,2,2-trifluoroethyl)carbamate

Base Information

Chemical Name:Methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)(2,2,2-trifluoroethyl)carbamate
CAS No.:1234572-70-3
Molecular Formula:C₂₁H₁₇F₄N₇O₂S
Molecular Weight:507.471
Hs Code.:

Synonyms:Methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)(2,2,2-trifluoroethyl)carbamate

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Chemical Property of Methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)(2,2,2-trifluoroethyl)carbamate

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Technology Process of Methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)(2,2,2-trifluoroethyl)carbamate

There total 5 articles about Methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)(2,2,2-trifluoroethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 23199-56-6
2,2,2-trifluoroethyltrichloromethanesulfonate

: 1234572-55-4
methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate

: 1234572-70-3
Methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)(2,2,2-trifluoroethyl)carbamate

Guidance literature:: methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)carbamate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

2,2,2-trifluoroethyltrichloromethanesulfonate; In tetrahydrofuran; mineral oil; at 20 ℃; for 48h;

Reference yield:

: 2557-78-0
2-fluorothiophenol

: 1234572-70-3
Methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)(2,2,2-trifluoroethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / copper(l) iodide / isopropyl alcohol; ethylene glycol / 20 h / 130 °C

2.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide; toluene / 17 h / 90 °C / Inert atmosphere

3.1: hydrogen; pyridine / palladium 10% on activated carbon / 17 h / 20 °C / 2625.26 Torr

4.1: isopropyl alcohol; 1-methyl-pyrrolidin-2-one / 19 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

5.2: 48 h / 20 °C

With pyridine; hydrogen; sodium hydride; potassium carbonate; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; copper(l) iodide; palladium 10% on activated carbon; XPhos; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethylene glycol; N,N-dimethyl-formamide; isopropyl alcohol; toluene; mineral oil;

Reference yield:

: 1234572-77-0
2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}-5-nitropyrimidine-4,6-diamine

: 1234572-70-3
Methyl (4,6-diamino-2-{3-[(2-fluorophenyl)sulphanyl]-1H-indazol-1-yl}pyrimidin-5-yl)(2,2,2-trifluoroethyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; pyridine / palladium 10% on activated carbon / 17 h / 20 °C / 2625.26 Torr

2.1: isopropyl alcohol; 1-methyl-pyrrolidin-2-one / 19 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 48 h / 20 °C

With pyridine; hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; isopropyl alcohol; mineral oil;