3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid

Base Information

• Chemical Name: 3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid
• CAS No.: 130979-65-6
• Molecular Formula: C₁₆H₁₄ClNO₆S
• Molecular Weight: 383.809

Synonyms:3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid

Chemical Property of 3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid

Chemical Property:

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Technology Process of 3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid

There total 3 articles about 3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid methyl ester (130979-64-5) → 3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid (130979-65-6)

Guidance literature:

With sodium hydroxide; In methanol; for 8h; Ambient temperature;

DOI:10.1021/jm00106a032

Reference yield:

2-nitro-5-chlorothiophenol (14371-79-0) → 3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid (130979-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / NaHCO₃ / ethanol; benzene / 4 h / Ambient temperature

2: 87.6 percent / 10percent NaOH / methanol / 8 h / Ambient temperature

With sodium hydroxide; sodium hydrogencarbonate; In methanol; ethanol; benzene;

DOI:10.1021/jm00106a032

Reference yield:

methyl trans-3-(4-methoxyphenyl)glycidate (96125-49-4) → 3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid (130979-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / NaHCO₃ / ethanol; benzene / 4 h / Ambient temperature

2: 87.6 percent / 10percent NaOH / methanol / 8 h / Ambient temperature

With sodium hydroxide; sodium hydrogencarbonate; In methanol; ethanol; benzene;

DOI:10.1021/jm00106a032

upstream raw materials:

3-(5-Chloro-2-nitro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid methyl ester

2-nitro-5-chlorothiophenol

methyl trans-3-(4-methoxyphenyl)glycidate

Downstream raw materials:

Acetic acid (2R,3S)-8-chloro-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester

(2R,3S)-8-Chloro-5-(2-dimethylamino-ethyl)-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one

(+/-)-trans-(2R,3S)-8-chloro-2,3-dihydro-3-hydroxy-2-(4'-methoxyphenyl)-1,5-benzothiazepin-4-[5H]-one

3-(2-Amino-5-chloro-phenylsulfanyl)-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid

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