benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate

Base Information

Chemical Name:benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate
CAS No.:1414627-40-9
Molecular Formula:C₄₄H₃₃NO₅
Molecular Weight:655.75
Hs Code.:

Synonyms:benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate

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Chemical Property of benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate

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Technology Process of benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate

There total 5 articles about benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1243583-64-3
benzyl 2,4-bis(benzyloxy)-6-(((trifluoromethyl)sulfonyl)-oxy) benzoate

: 1396008-49-3
2-(4-ethynylbenzyl)benzo[d]oxazole

: 1414627-40-9
benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diethylamine; In acetonitrile; at 100 ℃; for 0.333333h; Inert atmosphere; Microwave irradiation;
DOI:10.1016/j.bmc.2012.06.019

Reference yield:

: 931611-48-2
C₁₄H₁₂BrNO₂

: 1414627-40-9
benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / toluene / 4 h / Reflux

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine; triphenylphosphine / acetonitrile / 0.58 h / 120 °C / Inert atmosphere; Microwave irradiation

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / acetonitrile / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; diethylamine; triphenylphosphine; In tetrahydrofuran; toluene; acetonitrile; 2: Sonogashira coupling / 4: Sonogashira coupling;
DOI:10.1016/j.bmc.2012.06.019

Reference yield:

: 1396008-55-1
2-(4-((trimethylsilyl)ethynyl)benzyl)benzo[d]oxazole

: 1414627-40-9
benzyl 2-((4-(benzo[d]oxazol-2-ylmethyl)phenyl)ethynyl)-4,6-bis(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.17 h / 0 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / acetonitrile / 0.33 h / 100 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; diethylamine; In tetrahydrofuran; acetonitrile; 2: Sonogashira coupling;
DOI:10.1016/j.bmc.2012.06.019