Methyl N-(mesitylsulfonyl)-O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate

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Chemical Name:Methyl N-(mesitylsulfonyl)-O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate
CAS No.:441348-16-9
Molecular Formula:C₂₉H₃₅N₃O₆S
Molecular Weight:553.679
Hs Code.:

Synonyms:Methyl N-(mesitylsulfonyl)-O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate

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Chemical Property of Methyl N-(mesitylsulfonyl)-O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate

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Technology Process of Methyl N-(mesitylsulfonyl)-O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate

There total 6 articles about Methyl N-(mesitylsulfonyl)-O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 773-64-8
2-mesitylenesulphonyl chloride

: 757181-19-4
(S)-2-Amino-3-[3'-(3-propyl-ureido)-biphenyl-4-yloxy]-propionic acid methyl ester

: 441348-16-9
Methyl N-(mesitylsulfonyl)-O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/S0960-894X(03)00023-4

Reference yield:

: 773-64-8
2-mesitylenesulphonyl chloride

: 441348-13-6
Methyl O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate Hydro-Chloride

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 441348-16-9
Methyl N-(mesitylsulfonyl)-O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate

Guidance literature:: In dichloromethane; ethyl acetate;

Reference yield:

: 106-41-2
4-bromo-phenol

: 441348-16-9
Methyl N-(mesitylsulfonyl)-O-(3'-{[(propylamino)carbonyl]amino}-1,1'-biphenyl-4-yl)-L-serinate

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / PPh₃; DEAD / toluene / 15 h / 20 °C

2: 40 percent / AsPh₃; Pd(Ph₃P)2Cl₂; Cs₂CO₃ / 1,2-dimethoxy-ethane / 3 h / 20 °C

3: 70 percent / DABCO / toluene / 14 h / 20 °C

4: 30 percent / HCl / methanol; dioxane / 2 h / 20 °C

5: 40 percent / diisopropylethylamine / CH₂Cl₂ / 24 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; triphenyl-arsane; caesium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; dichloromethane; toluene; 2: Suzuki coupling;
DOI:10.1016/S0960-894X(03)00023-4