N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide

Base Information

Chemical Name:N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide
CAS No.:1421373-53-6
Molecular Formula:C₂₆H₂₈N₈O₂
Molecular Weight:484.561
Hs Code.:

Synonyms:N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide

Suppliers and Price of N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide

There total 17 articles about N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 1421372-35-1
6-methoxy-4-(4-methylpiperazin-1-yl)-N₁-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 814-68-6,25189-84-8
acryloyl chloride

: 1421373-53-6
N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h; Cooling;
DOI:10.1021/jm400822z

Reference yield: 28.0%

: 1421372-35-1
6-methoxy-4-(4-methylpiperazin-1-yl)-N₁-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine

: 71195-85-2
(2,3,4,5,6-pentafluorophenyl) prop-2-enoate

: 1421373-53-6
N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 1421372-05-5
2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrobenzoic acid

: 1421373-53-6
N-(4-methoxy-2-(4-methylpiperazin-1-yl)-5-(4-(pyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine; diphenylphosphoranyl azide / 2 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: methanesulfonic acid / water; butan-1-ol / 1 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / ethanol / 18 h / 20 °C

4.2: 2 h / 20 °C

5.1: N,N,N',N'-tetramethylguanidine / 2-methoxy-ethanol / 0.75 h / 120 - 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

With methanesulfonic acid; palladium 10% on activated carbon; diphenylphosphoranyl azide; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N,N,N',N'-tetramethylguanidine; In ethanol; dichloromethane; 2-methoxy-ethanol; water; N,N-dimethyl-formamide; butan-1-ol;