(3aR,5S,5aR,8aR)-7-(2-Methoxy-benzyl)-2,2,5-trimethyl-hexahydro-1,3-dioxa-7-aza-cyclopenta[c]pentalen-5-ol

Base Information

Chemical Name:(3aR,5S,5aR,8aR)-7-(2-Methoxy-benzyl)-2,2,5-trimethyl-hexahydro-1,3-dioxa-7-aza-cyclopenta[c]pentalen-5-ol
CAS No.:276246-12-9
Molecular Formula:C₁₉H₂₇NO₄
Molecular Weight:333.428
Hs Code.:

Synonyms:(3aR,5S,5aR,8aR)-7-(2-Methoxy-benzyl)-2,2,5-trimethyl-hexahydro-1,3-dioxa-7-aza-cyclopenta[c]pentalen-5-ol

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Chemical Property of (3aR,5S,5aR,8aR)-7-(2-Methoxy-benzyl)-2,2,5-trimethyl-hexahydro-1,3-dioxa-7-aza-cyclopenta[c]pentalen-5-ol

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Technology Process of (3aR,5S,5aR,8aR)-7-(2-Methoxy-benzyl)-2,2,5-trimethyl-hexahydro-1,3-dioxa-7-aza-cyclopenta[c]pentalen-5-ol

There total 3 articles about (3aR,5S,5aR,8aR)-7-(2-Methoxy-benzyl)-2,2,5-trimethyl-hexahydro-1,3-dioxa-7-aza-cyclopenta[c]pentalen-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 6850-57-3
2-methoxybenzylamine

: 276246-09-4
C₂₅H₃₂O₉S₂

: 276246-12-9
(3aR,5S,5aR,8aR)-7-(2-Methoxy-benzyl)-2,2,5-trimethyl-hexahydro-1,3-dioxa-7-aza-cyclopenta[c]pentalen-5-ol

Guidance literature:: In tetrahydrofuran; for 48h; Heating;
DOI:10.1021/np9905517

Reference yield:

: 196859-81-1
5,6:4',6'-di-O-isopropylidene-antirrhinoside

: 276246-12-9
(3aR,5S,5aR,8aR)-7-(2-Methoxy-benzyl)-2,2,5-trimethyl-hexahydro-1,3-dioxa-7-aza-cyclopenta[c]pentalen-5-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiAlH₄ / tetrahydrofuran / 4 h / Heating

1.2: O₃ / CH₂Cl₂; methanol / 0.5 h / -78 °C

1.3: 67.5 percent / NaBH₄ / ethanol / -65 - 20 °C

2.1: 99 percent / CH₂Cl₂; pyridine / -78 - -10 °C

3.1: 83 percent / tetrahydrofuran / 48 h / Heating

With lithium aluminium tetrahydride; In tetrahydrofuran; pyridine; dichloromethane; 1.1: Reduction / 1.2: ozonolysis / 1.3: Reduction / 2.1: Tosylation / 3.1: Cyclization;
DOI:10.1021/np9905517

Reference yield:

: 276246-08-3
(3aR,4R,5S,6aR)-3a,4-Bis-hydroxymethyl-2,2,5-trimethyl-tetrahydro-cyclopenta[1,3]dioxol-5-ol

: 276246-12-9
(3aR,5S,5aR,8aR)-7-(2-Methoxy-benzyl)-2,2,5-trimethyl-hexahydro-1,3-dioxa-7-aza-cyclopenta[c]pentalen-5-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / CH₂Cl₂; pyridine / -78 - -10 °C

2: 83 percent / tetrahydrofuran / 48 h / Heating

In tetrahydrofuran; pyridine; dichloromethane; 1: Tosylation / 2: Cyclization;
DOI:10.1021/np9905517