1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole

Base Information

• Chemical Name: 1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole
• CAS No.: 1313861-85-6
• Molecular Formula: C₁₇H₁₆N₂O₂
• Molecular Weight: 280.326
• Mol file: 1313861-85-6.mol

Synonyms:1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole

Chemical Property of 1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole

There total 6 articles about 1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

1-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)-propane-1,3-dione (6310-45-8) + methylhydrazine (60-34-4) → 1-methyl-3-(2'-hydroxyphenyl)-5-(2''-methoxyphenyl)pyrazole (1313861-87-8) + C16H14N2O2 (1202243-65-9) + 1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole (1313861-85-6)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.1016/j.molstruc.2011.04.014

Reference yield:

2-(2-methoxybenzoyloxy)acetophenone (40316-66-3) → 1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole (1313861-85-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

2: ethanol / 6 h

With potassium tert-butylate; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bioorg.2022.105658

Reference yield:

2-Methoxybenzoyl chloride (21615-34-9) → 1-methyl-5-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)pyrazole (1313861-85-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 1 h / 20 °C / Cooling with ice

2: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Cooling with ice

3: ethanol / 6 h

With pyridine; potassium tert-butylate; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bioorg.2022.105658

upstream raw materials:

1-(2'-hydroxyphenyl)-3-(2''-methoxyphenyl)-propane-1,3-dione

methylhydrazine

2-Methoxybenzoic acid

2-Methoxybenzoyl chloride