Technology Process of N-(1-tert-butyl-1H-imidazol-2-yl)-N'-(3,4-dichlorophenyl)guanidine hydrochloride
There total 4 articles about N-(1-tert-butyl-1H-imidazol-2-yl)-N'-(3,4-dichlorophenyl)guanidine hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia; isobutyryl chloride;
In
methanol; N,N-dimethyl-formamide;
at 20 ℃;
for 18h;
Inert atmosphere;
DOI:10.1021/jm200503s
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 18 h / 80 °C / Inert atmosphere; sealed tube
2.1: acetic acid / water / 1 h / 20 - 100 °C / Inert atmosphere
2.2: 0.25 h / 100 °C / Inert atmosphere
3.1: dichloromethane / 18 h / 20 °C / Inert atmosphere
4.1: ammonia; isobutyryl chloride / methanol; N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
With
ammonia; acetic acid; isobutyryl chloride;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200503s
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: acetic acid / water / 1 h / 20 - 100 °C / Inert atmosphere
1.2: 0.25 h / 100 °C / Inert atmosphere
2.1: dichloromethane / 18 h / 20 °C / Inert atmosphere
3.1: ammonia; isobutyryl chloride / methanol; N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere
With
ammonia; acetic acid; isobutyryl chloride;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm200503s
