1-BENZYL-1H-IMIDAZOL-2-YLAMINE

Base Information

• Chemical Name: 1-BENZYL-1H-IMIDAZOL-2-YLAMINE
• CAS No.: 22944-67-8
• Molecular Formula: C10H11 N3
• Molecular Weight: 173.217
• Hs Code.: 2933290090
• Mol file: 22944-67-8.mol

Synonyms:Imidazole,2-amino-1-benzyl- (8CI)

Chemical Property of 1-BENZYL-1H-IMIDAZOL-2-YLAMINE

Chemical Property:

• Vapor Pressure: 3.66E-06mmHg at 25°C
• Refractive Index: 1.622
• Boiling Point: 386°C at 760 mmHg
• Flash Point: 187.2°C
• PSA: 43.84000
• Density: 1.16g/cm³
• LogP: 2.09480

Purity/Quality:

99% ^*data from raw suppliers

1-benzyl-1H-imidazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BENZYL-1H-IMIDAZOL-2-YLAMINE

There total 4 articles about 1-BENZYL-1H-IMIDAZOL-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

CYANAMID (420-04-2) + N-benzyl-2,2-dimethoxyethylamine (54879-88-8) → 1-benzyl-1H-imidazol-2-ylamine (22944-67-8)

Guidance literature:

CYANAMID; N-benzyl-2,2-dimethoxyethylamine; With acetic acid; In water; at 20 - 100 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In water; at 100 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/jm200503s

Reference yield:

1-benzyl-2-nitro-1H-imidazole (501650-56-2) → 1-benzyl-1H-imidazol-2-ylamine (22944-67-8)

Guidance literature:

With hydrogen; nickel; In methanol; at 20 ℃; for 3h;

Reference yield:

benzyl chloride (100-44-7) → 1-benzyl-1H-imidazol-2-ylamine (22944-67-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 72 h / Reflux

2: hydrogen / nickel / methanol / 3 h / 20 °C

With hydrogen; triethylamine; nickel; In methanol; dichloromethane;

upstream raw materials:

1-benzyl-2-nitro-1H-imidazole

CYANAMID

N-benzyl-2,2-dimethoxyethylamine

benzyl chloride

Downstream raw materials:

1-(1-benzyl-1H-imidazol-2-yl)-3-(3,4-dichlorophenyl)thiourea

N-(1-tert-butyl-1H-imidazol-2-yl)-N'-(3,4-dichlorophenyl)guanidine hydrochloride

N-(1-benzyl-1H-imidazol-2-yl)-N'-(3,4-dichlorophenyl)-N''-isopropylguanidine

N-(1-benzyl-1H-imidazol-2-yl)-N'-(3,4-dichlorophenyl)-N''-isobutyrylguanidine