3-chloro-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione

Base Information

Chemical Name:3-chloro-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione
CAS No.:626605-37-6
Molecular Formula:C₂₀H₁₆ClN₃O₂
Molecular Weight:365.819
Hs Code.:

Synonyms:3-chloro-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione

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Chemical Property of 3-chloro-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione

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Technology Process of 3-chloro-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione

There total 4 articles about 3-chloro-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 626605-36-5
3-hydroxy-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione

: 626605-37-6
3-chloro-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione

Guidance literature:: With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; for 1h;
DOI:10.1016/j.bmc.2004.04.010

Reference yield:

: 626605-35-4
2-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]acetamide

: 626605-37-6
3-chloro-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / potassium tert-butoxide / dimethylformamide; tetrahydrofuran / 0.25 h

2: 89 percent / (COCl)2 / dimethylformamide; CH₂Cl₂ / 1 h

With oxalyl dichloride; potassium tert-butylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.04.010

Reference yield:

: 4414-87-3
1H-Pyrrolo[2,3-b]pyridin-3-yl-acetonitrile

: 626605-37-6
3-chloro-4-[1-(3-phenyl-propyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-pyrrole-2,5-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / H₂O₂; K₂CO₃ / H₂O; dimethylsulfoxide / 0.17 h

2: 49 percent / Cs₂CO₃ / dimethylformamide / 2 h / 70 °C

3: 81 percent / potassium tert-butoxide / dimethylformamide; tetrahydrofuran / 0.25 h

4: 89 percent / (COCl)2 / dimethylformamide; CH₂Cl₂ / 1 h

With oxalyl dichloride; potassium tert-butylate; dihydrogen peroxide; potassium carbonate; caesium carbonate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.04.010