2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide

Base Information

• Chemical Name: 2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide
• CAS No.: 1073119-18-2
• Molecular Formula: C₂₁H₂₂Cl₂N₄O₃
• Molecular Weight: 449.337

Synonyms:2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide

Chemical Property of 2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide

Chemical Property:

Purity/Quality:

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Technology Process of 2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide

There total 1 articles about 2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid (1073119-45-5) + di-n-propylamine (142-84-7) → 2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide (1073119-18-2)

Guidance literature:

2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid; With 1,1'-carbonyldiimidazole; at 20 ℃; Inert atmosphere;

di-n-propylamine; With triethylamine; Inert atmosphere;

DOI:10.1021/jm8006728

Reference yield: 68.0%

2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide (1073119-18-2) → 2-(2-(4-aminophenyl)-6,8-dichloroimidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide (1073119-51-3)

Guidance literature:

With hydrogenchloride; tin; In ethanol; water; for 2h; Reflux; Inert atmosphere;

DOI:10.1021/jm8006728

upstream raw materials:

2-(6,8-dichloro-2-(4-nitrophenyl)imidazo[1,2-a]pyridin-3-yl)acetic acid

di-n-propylamine

Downstream raw materials:

2-(2-(4-aminophenyl)-6,8-dichloroimidazo[1,2-a]pyridin-3-yl)-N,N-dipropylacetamide

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