5-chloro-2-[2-(3-chloropyridin-2-yl)-4-trifluoromethyl-benzoylamino]-N-dimethylcarbamoylmethoxy-3-methylbenzamide

Base Information

Chemical Name:5-chloro-2-[2-(3-chloropyridin-2-yl)-4-trifluoromethyl-benzoylamino]-N-dimethylcarbamoylmethoxy-3-methylbenzamide
CAS No.:1423022-38-1
Molecular Formula:C₂₅H₂₁Cl₂F₃N₄O₄
Molecular Weight:569.367
Hs Code.:

Synonyms:5-chloro-2-[2-(3-chloropyridin-2-yl)-4-trifluoromethyl-benzoylamino]-N-dimethylcarbamoylmethoxy-3-methylbenzamide

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Chemical Property of 5-chloro-2-[2-(3-chloropyridin-2-yl)-4-trifluoromethyl-benzoylamino]-N-dimethylcarbamoylmethoxy-3-methylbenzamide

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Technology Process of 5-chloro-2-[2-(3-chloropyridin-2-yl)-4-trifluoromethyl-benzoylamino]-N-dimethylcarbamoylmethoxy-3-methylbenzamide

There total 4 articles about 5-chloro-2-[2-(3-chloropyridin-2-yl)-4-trifluoromethyl-benzoylamino]-N-dimethylcarbamoylmethoxy-3-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 138224-86-9
2-(aminooxy)-N,N-dimethylacetamide

: 1423022-49-4
6-chloro-2-[2-(3-chloro-pyridin-2-yl)-4-trifluoromethyl-phenyl]-8-methylbenzo[d][1,3]oxazin-4-one

: 1423022-38-1
5-chloro-2-[2-(3-chloropyridin-2-yl)-4-trifluoromethyl-benzoylamino]-N-dimethylcarbamoylmethoxy-3-methylbenzamide

Guidance literature:: In tetrahydrofuran; for 24h; Reflux;

Reference yield:

: 444993-17-3
4-trifluoromethyl-benzoic acid isopropyl ester

: 1423022-38-1
5-chloro-2-[2-(3-chloropyridin-2-yl)-4-trifluoromethyl-benzoylamino]-N-dimethylcarbamoylmethoxy-3-methylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2 h / 0 °C

1.2: 1.5 h / 22 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 30 - 110 °C / Inert atmosphere

2.2: 70 °C

3.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 - 5 °C

3.2: 0 - 20 °C

4.1: tetrahydrofuran / 24 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; water; acetonitrile;

Reference yield:

: 329-15-7
4-trifluoromethyl-phenyl acetyl chloride

: 1423022-38-1
5-chloro-2-[2-(3-chloropyridin-2-yl)-4-trifluoromethyl-benzoylamino]-N-dimethylcarbamoylmethoxy-3-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / 4 h / 22 °C

2.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 2 h / 0 °C

2.2: 1.5 h / 22 °C

3.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 20 h / 30 - 110 °C / Inert atmosphere

3.2: 70 °C

4.1: triethylamine; methanesulfonyl chloride / acetonitrile / 0.5 h / 0 - 5 °C

4.2: 0 - 20 °C

5.1: tetrahydrofuran / 24 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; methanesulfonyl chloride; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; n-heptane; ethylbenzene; water; acetonitrile;