3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester

Base Information

Chemical Name:3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester
CAS No.:791046-06-5
Molecular Formula:C₂₈H₃₀N₆O₃
Molecular Weight:498.585
Hs Code.:

3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1<i>H</i>-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester

Synonyms:3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester

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Chemical Property of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester

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Technology Process of 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester

There total 11 articles about 3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 211915-73-0
1-methyl-2-[N-(4-cyanophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide

: 791046-06-5
3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester

Guidance literature:: 1-methyl-2-[N-(4-cyanophenyl)-aminomethyl]-benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)-amide; With hydrogenchloride; In ethanol; at 20 ℃; for 12h;

With ammonia; In ethanol; at 20 ℃; for 5h; Reagent/catalyst; Solvent;

Reference yield:

: 82357-48-0
4-methylamino-3-nitro-benzoic acid chloride

: 791046-06-5
3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / tetrahydrofuran / 20 °C

2.1: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

3.1: CDI / tetrahydrofuran / 50 °C

4.1: AcOH / Heating

5.1: HCl / ethanol / 0 °C

5.2: (NH₄)2CO₃ / ethanol / 20 °C

With hydrogenchloride; hydrogen; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; 5.1: Pinner reaction;
DOI:10.1021/jm0109513

Reference yield:

: 41263-74-5
4-(methylamino)-3-nitrobenzoic acid

: 791046-06-5
3-({2-[(4-carbamimidoyl-phenylamino)-methyl]-1-methyl-1H-benzoimidazole-5-carbonyl}-phenyl-amino)-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: SOCl₂ / dimethylformamide / 0.5 h / Heating

2.1: Et₃N / tetrahydrofuran / 20 °C

3.1: H₂ / 10percent Pd/C / methanol; CH₂Cl₂ / 20 °C

4.1: CDI / tetrahydrofuran / 50 °C

5.1: AcOH / Heating

6.1: HCl / ethanol / 0 °C

6.2: (NH₄)2CO₃ / ethanol / 20 °C

With hydrogenchloride; thionyl chloride; hydrogen; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; 10percent Pd/C; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; 6.1: Pinner reaction;
DOI:10.1021/jm0109513