(4S,6S)-4-Iodomethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Base Information

Chemical Name:(4S,6S)-4-Iodomethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane
CAS No.:815588-00-2
Molecular Formula:C₁₇H₂₅IO₄
Molecular Weight:420.288
Hs Code.:

Synonyms:(4S,6S)-4-Iodomethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,6S)-4-Iodomethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Chemical Property:

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Technology Process of (4S,6S)-4-Iodomethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

There total 5 articles about (4S,6S)-4-Iodomethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Toluene-4-sulfonic acid (4S,6S)-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-ylmethyl ester

: 815588-00-2
(4S,6S)-4-Iodomethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Guidance literature:: With sodium hydrogencarbonate; sodium iodide; In butanone; for 8h; Heating;
DOI:10.1055/s-2004-831334

Reference yield:

: 629614-61-5
2-((4S,6S)-2,2-Dimethyl-6-vinyl-[1,3]dioxan-4-yl)-ethanol

: 815588-00-2
(4S,6S)-4-Iodomethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 4 steps

1.1: CSA / CH₂Cl₂ / 20 h / 20 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 71 percent / NaBH₄ / aq. ethanol / 1.5 h / 20 °C

3.1: DMAP; Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

4.1: NaI; NaHCO₃ / butan-2-one / 8 h / Heating

With dmap; camphor-10-sulfonic acid; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; In dichloromethane; butanone;
DOI:10.1055/s-2004-831334

Reference yield:

: 815588-08-0
ethyl 2-((4S,6R)-2,2-dimethyl-6-vinyl-1,3-dioxan-4-yl)acetate

: 815588-00-2
(4S,6S)-4-Iodomethyl-6-[2-(4-methoxy-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 5 steps

1.1: LiAlH₄ / tetrahydrofuran / 0.17 h / 0 °C

2.1: CSA / CH₂Cl₂ / 20 h / 20 °C

3.1: O₃ / CH₂Cl₂ / -78 °C

3.2: 71 percent / NaBH₄ / aq. ethanol / 1.5 h / 20 °C

4.1: DMAP; Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

5.1: NaI; NaHCO₃ / butan-2-one / 8 h / Heating

With dmap; lithium aluminium tetrahydride; camphor-10-sulfonic acid; sodium hydrogencarbonate; ozone; triethylamine; sodium iodide; In tetrahydrofuran; dichloromethane; butanone;
DOI:10.1055/s-2004-831334