Technology Process of 3-(4-hydroxymethyl-2,6-dimethoxyphenyl)propan-1-ol
There total 5 articles about 3-(4-hydroxymethyl-2,6-dimethoxyphenyl)propan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(4-formyl-2,6-dimethoxyphenyl)acrylic acid;
With
palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine;
In
ethanol;
for 16h;
under 750.075 Torr;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 3h;
Reflux;
- Guidance literature:
-
3-(4-hydroxymethyl-2,6-dimethoxyphenyl)propionic acid;
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
for 2h;
Reflux;
With
hydrogenchloride;
In
water;
pH=1 - 2;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / dichloromethane / 16 h / 0 - 20 °C
2.1: 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate / N,N-dimethyl-formamide / 16 h / 115 °C / Inert atmosphere
3.1: methanol; sodium hydroxide / 16 h / 20 °C
4.1: palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 750.08 Torr
4.2: 3 h / Reflux
With
pyridine; methanol; palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; hydrogen; palladium diacetate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
