4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile

Base Information

Chemical Name:4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile
CAS No.:943826-95-7
Molecular Formula:C₁₉H₁₆ClN₅O₂
Molecular Weight:381.821
Hs Code.:

Synonyms:4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile

Suppliers and Price of 4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile

There total 4 articles about 4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 943826-93-5
4-[2-(4-cyanophenylamino)pyrimidin-4-ylamino]-3-chloro-5-methoxybenzoic acid ethyl ester

: 943826-95-7
4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 20h;
DOI:10.1016/j.ejmech.2006.11.014

Reference yield:

: 943826-92-4
4-amino-3-chloro-5-methoxybenzoic acid ethyl ester

: 943826-95-7
4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrochloric acid / 16 h / Heating

2: 67 percent / LiAlH₄ / tetrahydrofuran / 20 h / 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2006.11.014

Reference yield:

: 2486-69-3
3-methoxy-4-aminobenzoic acid

: 943826-95-7
4-[4-(4-hydroxymethyl-2-chloro-6-methoxyphenylamino)pyrimidin-4-ylamino]benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / thionyl chloride / 3 h / Heating

2: 73 percent / N-chlorosuccinimide / acetonitrile / 1 h / Heating

3: hydrochloric acid / 16 h / Heating

4: 67 percent / LiAlH₄ / tetrahydrofuran / 20 h / 0 - 20 °C

With hydrogenchloride; N-chloro-succinimide; lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.ejmech.2006.11.014