(Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-yl methylsulfonate

Base Information

Chemical Name:(Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-yl methylsulfonate
CAS No.:293299-45-3
Molecular Formula:C₁₃H₁₈BrNO₅S₂
Molecular Weight:412.326
Hs Code.:

Synonyms:(Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-yl methylsulfonate

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Chemical Property of (Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-yl methylsulfonate

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Technology Process of (Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-yl methylsulfonate

There total 5 articles about (Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-yl methylsulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 405932-42-5
(Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-ol

: 293299-45-3
(Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-yl methylsulfonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at -78 - 0 ℃; for 2h;
DOI:10.1021/jo016320y

Reference yield:

: 13379-98-1
3-[N-(4-methylphenylsulfonyl)amino]propan-1-ol

: 293299-45-3
(Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-yl methylsulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl)2; DMSO; diisopropylethylamine / CH₂Cl₂ / 1.33 h / -78 °C

2: 3.96 g / CHCl₃ / 19 h / 0 °C

3: 95 percent / DIBAL-H / CHCl₃; toluene / 2 h / -78 °C

4: 99 percent / Et₃N / tetrahydrofuran / 2 h / -78 - 0 °C

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; chloroform; toluene;
DOI:10.1021/jo016320y

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 293299-45-3
(Z)-2-bromo-5-[N-(4-methylphenylsulfonyl)amino]pent-2-en-1-yl methylsulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 17 h / 0 °C

2: (COCl)2; DMSO; diisopropylethylamine / CH₂Cl₂ / 1.33 h / -78 °C

3: 3.96 g / CHCl₃ / 19 h / 0 °C

4: 95 percent / DIBAL-H / CHCl₃; toluene / 2 h / -78 °C

5: 99 percent / Et₃N / tetrahydrofuran / 2 h / -78 - 0 °C

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; chloroform; toluene;
DOI:10.1021/jo016320y