Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

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Chemical Name:Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester
CAS No.:130718-58-0
Molecular Formula:C₃₂H₂₇ClN₄O₆
Molecular Weight:599.043
Hs Code.:

Synonyms:Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

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Chemical Property of Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

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Technology Process of Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

There total 2 articles about Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 530-62-1
1,1'-carbonyldiimidazole

: 52769-90-1
2'-chloro-2'-deoxy-5'-O-trityluridine

: 130718-58-0
Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: In acetonitrile;
DOI:10.1016/S0040-4039(00)97480-X

Reference yield:

: 76-83-5
trityl chloride

: 130718-58-0
Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / pyridine / 3.5 h / 120 °C

2: 84 percent / acetonitrile

With pyridine; In acetonitrile;
DOI:10.1016/S0040-4039(00)97480-X

Reference yield: 97.0%

: 130718-58-0
Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

: 130718-60-4
Imidazole-1-carboxylic acid (2R,3S,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 60 - 70 ℃;
DOI:10.1016/S0040-4039(00)97480-X