52769-90-1

Upstream product

• 3736-77-4 2,2'-Anhydrouridine 
• 76-83-5 trityl chloride 

Downstream Products

• 130718-59-1 Acetic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 130718-57-9 Imidazole-1-carbothioic acid O-[(2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl] ester 
• 127841-06-9 2'-chloro-3'-trifluoromethanesulfonyl-5'-O-trityl-2'-deoxyuridine 
• 127841-11-6 1-(2-chloro-2,3-dideoxy-5-O-trityl-β-D-glycero-pent-2-enofuranosyl)cytosine 
• 127841-07-0 1-(2-chloro-2,3-dideoxy-5-O-trityl-β-D-glycero-pent-2-enofuranosyl)uracil 
• 127841-09-2 1-(2-chloro-2,3-dideoxy-5-O-trityl-β-D-glycero-pent-2-enofuranosyl)-N⁴-hydroxycytosine 
• 115259-92-2 2'-chlorouridinene 
• 6038-55-7 1-(2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl-5-O-trityl)uracil 
• 121356-00-1 3'-O-acetyl-2'-deoxy-5'-O-triphenylmethyluridine 
• 130718-60-4 Imidazole-1-carboxylic acid (2R,3S,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester 
• 130718-58-0 Imidazole-1-carboxylic acid (2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-trityloxymethyl-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

A REGIOSPECIFIC SYNTHESIS OF UNSATURATED NUCLEOSIDES, CARBOHYDRATES AND OTHER OLEFINS

Vicinal disubstituted nucleosides, carbohydrates and cyclohexane derivatives with a pair of radical leaving groups, such as chloro, bromo, phenoxythiocarbonyloxy, and imidazolylthiocarbonyloxy groups, have been successfully converted to the corresponding olefins in high yields (60-90 percent) without observed side products, by reaction with tri-n-butyltin hydride and azobisisobutyronitrile in an appropriate solvent.

SYNTHESIS OF 2'-CHLORO-2',3'-DIDEOXY-2',3'-DIDEHYDRO NUCLEOSIDES

Treatment of O2,2'-anhydrouridine with triphenylmethyl chloride in pyridine at 80 deg C gives mainly the 2'-chlorinated nucleoside 3.Reaction of 2'-chloro-3'-O-trifluoromethanesulfonyl-5'-O-trityl-2'-deoxyuridine (4) with NaOH led exclusively t