(1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane

Base Information

• Chemical Name: (1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane
• CAS No.: 77890-94-9
• Molecular Formula: C₁₇H₂₄O₆S
• Molecular Weight: 356.44
• Mol file: 77890-94-9.mol

Synonyms:(1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane

Chemical Property of (1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane

There total 8 articles about (1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acrolein dimer (100-73-2) → (1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane (77890-94-9)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran; hexane / Ambient temperature

2: 92 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

4: MCPBA / CH₂Cl₂ / 72 h / Ambient temperature

5: 2. potassium fluoride / 1. -78 deg C/THF/5 min 2. MeOH/1 h/room temperature

With pyridine; potassium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo00193a015

Reference yield:

lithium bis(trimethylsilyl)(phenylthio)methylide (62762-44-1) → (1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane (77890-94-9)

Guidance literature:

Multi-step reaction with 5 steps

1: tetrahydrofuran; hexane / Ambient temperature

2: 92 percent / pyridine / CH₂Cl₂ / 0.5 h / 0 °C

4: MCPBA / CH₂Cl₂ / 72 h / Ambient temperature

5: 2. potassium fluoride / 1. -78 deg C/THF/5 min 2. MeOH/1 h/room temperature

With pyridine; potassium fluoride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1021/jo00193a015

Reference yield:

methyllithium (917-54-4) + 077943-81-8 (77890-93-8,77943-81-8) → (1S,2S,4S,6S)-4-((R)-2-Benzenesulfonyl-1-methyl-ethyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane (77890-94-9)

Guidance literature:

With potassium fluoride; Multistep reaction; 1.) THF, -78 deg C, 5 min;

DOI:10.1021/ja00382a065

upstream raw materials:

methyllithium

{(Z)-1-Benzenesulfonyl-2-[(1R,2R,4R,6R)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]hept-4-yl]-vinyl}-trimethyl-silane

077943-81-8

acrolein dimer

Downstream raw materials:

(1S,2S,4S,6S)-4-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-methoxy-ethoxy)-3,7-dioxa-bicyclo[4.1.0]heptane

(3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-2-(2-chloro-ethoxy)-3-methoxy-tetrahydro-pyran-4-ol

(2S,3S,4R,6S)-6-((E)-(R)-2-Benzenesulfonyl-1,3-dimethyl-hex-4-enyl)-3-methoxy-4-(4-methoxy-benzyloxy)-2-(2-methoxy-ethoxy)-tetrahydro-pyran

(E)-(2R,5S,6R)-7-Benzenesulfonyl-2,3,3-trimethoxy-6,8-dimethyl-undec-9-ene-1,5-diol