Boc-N-Me-Asp(OBzl)-OH

Base Information

Chemical Name:Boc-N-Me-Asp(OBzl)-OH
CAS No.:141408-45-9
Molecular Formula:C₁₇H₂₃NO₆
Molecular Weight:337.373
Hs Code.:
DSSTox Substance ID:DTXSID001136688

Synonyms:Boc-N-Me-Asp(OBzl)-OH;141408-45-9;(S)-4-(Benzyloxy)-2-((tert-butoxycarbonyl)(methyl)amino)-4-oxobutanoic acid;DTXSID001136688;4-(Phenylmethyl) hydrogen N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-aspartate

Suppliers and Price of Boc-N-Me-Asp(OBzl)-OH

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Boc-N-Me-Asp(OBzl)-OH

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:337.15253745
Heavy Atom Count:24
Complexity:451

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N(C)C(CC(=O)OCC1=CC=CC=C1)C(=O)O
Isomeric SMILES:CC(C)(C)OC(=O)N(C)[C@@H](CC(=O)OCC1=CC=CC=C1)C(=O)O

Technology Process of Boc-N-Me-Asp(OBzl)-OH

There total 4 articles about Boc-N-Me-Asp(OBzl)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 74-88-4
methyl iodide

: 141408-45-9
(S)-4-(benzyloxy)-2-((tert-butoxycarbonyl)(methyl)amino)-4-oxobutanoic acid

Guidance literature:: BOC-L-aspartic acid 4-benzyl ester; With sodium hexamethyldisilazane; In tetrahydrofuran; toluene; at 0 ℃;

methyl iodide; In tetrahydrofuran; toluene; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2018.12.002

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 141409-00-9
(S)-2-Methylamino-succinic acid 4-benzyl ester

: 141408-45-9
(S)-4-(benzyloxy)-2-((tert-butoxycarbonyl)(methyl)amino)-4-oxobutanoic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; water; at 35 ℃; for 1h; Yield given;
DOI:10.1021/jm00094a001

Reference yield:

: 150009-58-8,86060-84-6
9-fluorenylmethoxycarbonyl-O-benzyl-L-aspartic acid

: 141408-45-9
(S)-4-(benzyloxy)-2-((tert-butoxycarbonyl)(methyl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) p-TsOH*H₂O, 2.) TFA, triethylsilane / 1.) toluene, reflux, 2 h

2: piperidine / CH₂Cl₂; diisopropyl ether

3: N,N-diisopropylethylamine (DIEA) / CH₂Cl₂; H₂O / 1 h / 35 °C

With piperidine; triethylsilane; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; di-isopropyl ether; water;
DOI:10.1021/jm00094a001