(S)-2-Methyl-butyric acid (1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

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Chemical Name:(S)-2-Methyl-butyric acid (1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester
CAS No.:82065-68-7
Molecular Formula:C₃₉H₆₄O₆Si
Molecular Weight:657.019
Hs Code.:

(S)-2-Methyl-butyric acid (1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

Synonyms:(S)-2-Methyl-butyric acid (1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

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Chemical Property of (S)-2-Methyl-butyric acid (1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

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Technology Process of (S)-2-Methyl-butyric acid (1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

There total 2 articles about (S)-2-Methyl-butyric acid (1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 84131-91-9
(S)-(+)-2-methylbutyric anhydride

: 82065-67-6
(1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-ol

: 82065-68-7
(S)-2-Methyl-butyric acid (1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

Guidance literature:: With dmap; In pyridine; at 25 ℃; for 20h;
DOI:10.1021/ja00379a037

Reference yield:

: 82080-53-3
(4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-Benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-3,4,4a,7,8,8a-hexahydro-2H-naphthalen-1-one

: 82065-68-7
(S)-2-Methyl-butyric acid (1S,4S,4aR,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-benzyloxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-4-(tert-butyl-dimethyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / K-selectride / tetrahydrofuran / 25 °C

2: 70 percent / DMAP / pyridine / 20 h / 25 °C

With dmap; potassium tri-sec-butyl-borohydride; In tetrahydrofuran; pyridine;
DOI:10.1021/ja00379a037