({2-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-((R)-2-iodo-1-methyl-ethyl)-4-methylene-cyclohex-2-enyl]-ethyl}-dimethyl-silanyl)-benzene

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Chemical Name:({2-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-((R)-2-iodo-1-methyl-ethyl)-4-methylene-cyclohex-2-enyl]-ethyl}-dimethyl-silanyl)-benzene
CAS No.:828915-82-8
Molecular Formula:C₂₆H₄₃IOSi₂
Molecular Weight:554.702
Hs Code.:

Synonyms:({2-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-((R)-2-iodo-1-methyl-ethyl)-4-methylene-cyclohex-2-enyl]-ethyl}-dimethyl-silanyl)-benzene

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Chemical Property of ({2-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-((R)-2-iodo-1-methyl-ethyl)-4-methylene-cyclohex-2-enyl]-ethyl}-dimethyl-silanyl)-benzene

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Technology Process of ({2-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-((R)-2-iodo-1-methyl-ethyl)-4-methylene-cyclohex-2-enyl]-ethyl}-dimethyl-silanyl)-benzene

There total 11 articles about ({2-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-((R)-2-iodo-1-methyl-ethyl)-4-methylene-cyclohex-2-enyl]-ethyl}-dimethyl-silanyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 828915-81-7
(R)-2-{(3S,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-3-[2-(dimethyl-phenyl-silanyl)-ethyl]-6-methylene-cyclohex-1-enyl}-propan-1-ol

: 828915-82-8
({2-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-((R)-2-iodo-1-methyl-ethyl)-4-methylene-cyclohex-2-enyl]-ethyl}-dimethyl-silanyl)-benzene

Guidance literature:: With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran; acetonitrile; at -20 - 20 ℃;
DOI:10.1002/anie.200460936

Reference yield:

: 15109-94-1
1-(2-furyl)-2-bromoethanone

: 828915-82-8
({2-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-((R)-2-iodo-1-methyl-ethyl)-4-methylene-cyclohex-2-enyl]-ethyl}-dimethyl-silanyl)-benzene

Guidance literature:: Multi-step reaction with 8 steps

1.1: Et₃N; HCO₂H / [Cp*RhCl((R,R)-(-)-N-(p-Ts)-1,2-diphenylethylenediamine)] / ethyl acetate / 4 h / 0 °C

2.1: K₂CO₃ / acetonitrile / 14 h / 20 °C

3.1: 7.22 g / diethyl ether / -78 - 20 °C

4.1: Et₃N / CH₂Cl₂ / 16 h / 20 °C

4.2: BHT / ethyl acetate / 120 °C / microwave irradiation

5.1: 99 percent / imidazole; DMAP / dimethylformamide / 18 h / 20 °C

6.1: 81 percent / TBAF / tetrahydrofuran / 38 h / 0 °C

7.1: 84 percent / Ph₃P; I₂; imidazole / tetrahydrofuran; acetonitrile / 5 h / -20 - 20 °C

With 1H-imidazole; dmap; formic acid; tetrabutyl ammonium fluoride; iodine; potassium carbonate; triethylamine; triphenylphosphine; [Cp*RhCl((R,R)-(-)-N-(p-Ts)-1,2-diphenylethylenediamine)]; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200500739

Reference yield:

: 445399-68-8
(2S)-2-(furan-2-yl)propan-1-ol

: 828915-82-8
({2-[(1S,6R)-6-(tert-Butyl-dimethyl-silanyloxy)-3-((R)-2-iodo-1-methyl-ethyl)-4-methylene-cyclohex-2-enyl]-ethyl}-dimethyl-silanyl)-benzene

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N / CH₂Cl₂ / 16 h / 20 °C

1.2: BHT / ethyl acetate / 120 °C / microwave irradiation

2.1: 99 percent / imidazole; DMAP / dimethylformamide / 18 h / 20 °C

3.1: 81 percent / TBAF / tetrahydrofuran / 38 h / 0 °C

4.1: 84 percent / Ph₃P; I₂; imidazole / tetrahydrofuran; acetonitrile / 5 h / -20 - 20 °C

With 1H-imidazole; dmap; tetrabutyl ammonium fluoride; iodine; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200500739