(3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone

Base Information

• Chemical Name: (3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone
• CAS No.: 130193-84-9
• Molecular Formula: C₃₈H₄₅NO₅Si
• Molecular Weight: 623.864

Synonyms:(3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone

Chemical Property of (3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone

There total 6 articles about (3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p,p'-dimethoxybenzhydrylamine (19293-62-0) → (3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone (130193-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄ / toluene / 1 h / 0 °C

2: Et₃N / CH₂Cl₂ / Ambient temperature

With magnesium sulfate; triethylamine; In dichloromethane; toluene;

DOI:10.1016/S0040-4020(01)88510-0

Reference yield:

(R)-methyl mandelate (20698-91-3) → (3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone (130193-84-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / imidazole / dimethylformamide / Ambient temperature

2: 82 percent / DIBAL / hexane; diethyl ether / 0.33 h / -78 °C

3: MgSO₄ / toluene / 1 h / 0 °C

4: Et₃N / CH₂Cl₂ / Ambient temperature

With 1H-imidazole; diisobutylaluminium hydride; magnesium sulfate; triethylamine; In diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4020(01)88510-0

Reference yield:

(R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde (130115-07-0) → (3R,4R)-3-benzyloxy-4-<(R)-1-(t-butyldimethylsilyloxy)benzyl>-1-(di-p-anisylmethyl)-2-azetidinone (130193-84-9)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄ / toluene / 1 h / 0 °C

2: Et₃N / CH₂Cl₂ / Ambient temperature

With magnesium sulfate; triethylamine; In dichloromethane; toluene;

DOI:10.1016/S0040-4020(01)88510-0

upstream raw materials:

Benzyloxyacetyl chloride

[Bis-(4-methoxy-phenyl)-methyl]-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-eth-(E)-ylidene]-amine

p,p'-dimethoxybenzhydrylamine

(R)-methyl mandelate

Downstream raw materials:

(3R,4R)-3-benzyloxy-1-(di-p-anisylmethyl)-4-<(R)-1-hydroxybenzyl>-2-azetidinone

(2R,3S,4R)-3-Amino-2-benzyloxy-4-hydroxy-4-phenyl-butyric acid isopropyl ester

isopropyl (2R,3S,4R)-3-amino-2-benzyloxy-4-hydroxybutyrate

isopropyl (2R,3S)-3-acetamido-2-acetoxy-4-cyclohexylbutyrate

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