2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester

Base Information

• Chemical Name: 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester
• CAS No.: 119642-26-1
• Molecular Formula: C₁₃H₂₅NO₃
• Molecular Weight: 243.346
• Mol file: 119642-26-1.mol

Synonyms:2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester

Chemical Property of 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester

There total 34 articles about 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

isopropyl (2R,3S)-2-benzyloxy-4-cyclohexyl-3-<(S)-(1-phenylethyl)amino>butyrate (129397-43-9) → 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester (119642-26-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)88510-0

Reference yield: 97.0%

isopropyl (2R,3S)-3-amino-2-hydroxy-4-phenylbutyrate (119660-39-8) → 2(R)-hydroxy-3(S)-amino-4-cyclohexylbutanoic acid 2-propyl ester (119642-26-1)

Guidance literature:

With hydrogen; Rh/Al₂O₃; In acetic acid;

DOI:10.1016/S0040-4039(00)89018-8

Reference yield: 95.0%

isopropyl (2R*,3S*)-3-benzylamino-2-benzyloxy-4-cyclohexylbutyrate (129397-41-7,129482-89-9) → (2R*,3S*)-cyclohexylnorstatine isopropyl ester (119642-26-1,119832-69-8,129446-12-4,129567-61-9,139101-42-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In isopropyl alcohol; for 24h; under 760 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)88510-0

upstream raw materials:

isopropyl (2R,3S)-2-benzyloxy-4-cyclohexyl-3-<(S)-(1-phenylethyl)amino>butyrate

isopropyl (2R,3S)-3-amino-2-hydroxy-4-phenylbutyrate

(2R,3S)-2-Acetoxy-3-tert-butoxycarbonylamino-4-cyclohexyl-butyric acid isopropyl ester

Isopropyl 2R-Acetoxy-3S-carboxy-4-cyclohexylbutanoate

Downstream raw materials:

(2R,3S)-nor-C-statine hydrochloride

isopropyl (2R,3S)-3-acetamido-2-acetoxy-4-cyclohexylbutyrate

(2R,3S)-3-[(5-Chloro-1H-indole-2-carbonyl)-amino]-4-cyclohexyl-2-hydroxy-butyric acid isopropyl ester

(2S,3R)-2-Acetoxy-3-acetylamino-4-cyclohexyl-butyric acid isopropyl ester