4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide

Base Information

Chemical Name:4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide
CAS No.:1429240-70-9
Molecular Formula:C₃₂H₂₈Cl₂F₃N₅O₃S₂
Molecular Weight:722.639
Hs Code.:

4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide

Synonyms:4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide

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Chemical Property of 4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide

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Technology Process of 4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide

There total 9 articles about 4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1429242-17-0
4-(aminomethyl)-1-(2,4-dichlorophenyl)-5-(5-(2-(4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide

: 139631-62-2
cyclopropanesulfonyl chloride

: 1429240-70-9
4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at -30 ℃; for 1h;
DOI:10.1021/jm401158e

Reference yield:

: 1429241-32-6
4-(bromomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoro methyl)phenyl)ethynyl)thiophen-2-yl)-1H-pyrazole-3-carboxamide

: 1429240-70-9
4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

2: triphenylphosphine / water; tetrahydrofuran / 16 h / 20 °C

3: triethylamine / dichloromethane / 1 h / -30 °C

With sodium azide; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm401158e

Reference yield:

: 1013649-25-6
5-(5-bromothiophen-2-yl)-1-(2,4-dichloro-phenyl)-4-methyl-5-thiophen-2-yl-1H-pyrazole-3-carboxylic acid ethyl ester

: 1429240-70-9
4-(cyclopropanesulfonamidomethyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)-thiophene-2-yl)-1H-pyrazole-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 16 h / Reflux

2: silver nitrate / acetone; water / 16 h / 60 °C

3: aluminum (III) chloride / 16 h / 0 - 20 °C / Inert atmosphere

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 12 h / 80 °C / Inert atmosphere; Sealed tube

5: phosphorus tribromide / dichloromethane / 2 h / 0 - 20 °C

6: sodium azide / N,N-dimethyl-formamide / 3 h / 20 °C

7: triphenylphosphine / water; tetrahydrofuran / 16 h / 20 °C

8: triethylamine / dichloromethane / 1 h / -30 °C

With aluminum (III) chloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; sodium azide; 2,2'-azobis(isobutyronitrile); phosphorus tribromide; silver nitrate; triethylamine; triphenylphosphine; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm401158e