1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

Base Information

• Chemical Name: 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID
• CAS No.: 1123-28-0
• Molecular Formula: C7H12O3
• Molecular Weight: 144.17
• Hs Code.: 2918199090
• Mol file: 1123-28-0.mol

Synonyms:1-Hydroxy-1-cyclohexanecarboxylicacid;1-Hydroxycyclohexanecarboxylic acid;NSC 1182;NSC 143384;

Chemical Property of 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.00012mmHg at 25°C
• Melting Point: 107-108 °C
• Refractive Index: 1.53
• Boiling Point: 299.3 °C at 760 mmHg
• PKA: 3.99±0.20(Predicted)
• Flash Point: 149.1 °C
• PSA: 57.53000
• Density: 1.263 g/cm³
• LogP: 0.76620
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-Hydroxycyclohexanecarboxylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID

There total 42 articles about 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-trimethylsilanyloxycyclohexanecarbonitrile (24731-36-0) → 1-hydroxy-cyclohexanecarboxylic acid (1123-28-0)

Guidance literature:

With hydrogenchloride; water; at 20 - 60 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol302096j

Reference yield: 95.0%

Bromoform (75-25-2) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-hydroxy-cyclohexanecarboxylic acid (1123-28-0)

Guidance literature:

With potassium hydroxide; for 1h; Ambient temperature;

DOI:10.1248/cpb.47.684

Reference yield: 87.24%

1-hydroxy-1-cyclohexanecarbonitrile (931-97-5) → 1-hydroxy-cyclohexanecarboxylic acid (1123-28-0)

Guidance literature:

1-hydroxy-1-cyclohexanecarbonitrile; With cyclohexanone; chlorine; at 45 - 75 ℃; for 4h; Reflux;

With water; at 35 ℃; Reagent/catalyst; Temperature;

upstream raw materials:

2-chlorocycloheptanone

1-vinylcyclohexanol

1-hydroxy-1-cyclohexanecarbonitrile

1-benzoyloxy-cyclohexanecarboxylic acid amide

Downstream raw materials:

ethyl 1-hydroxycyclohexanecarboxylate

1-(1-hydroxycyclohexyl)ethan-1-one

2-(1-hydroxycyclohexyl)propan-2-ol

methyl cyclohex-1-ene-1-carboxylate

Refernces

• 1、 Powell,Farrell. "". . p. 2135. Retrieved 1968.
• 2、 -. "Anesthetic compounds and related methods of use". Page/Page column 65. . Retrieved 2015/11/09.
• 3、 Maegawa, Tomohiro,Otake, Kazuki,Hirosawa, Keiichi,Goto, Akihiro,Fujioka, Hiromichi. "Method for the efficient synthesis of highly-substituted oxetan- and azetidin-, dihydrofuran- and pyrrolidin-3-ones and its application to the synthesis of (±)-pseudodeflectusin". . p. 4798 - 4801. Retrieved 2013/01/15.