(2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid

Base Information

Chemical Name:(2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid
CAS No.:852233-70-6
Molecular Formula:C₃₂H₂₉N₅O₁₀
Molecular Weight:643.61
Hs Code.:

(2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid

Synonyms:(2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid

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Chemical Property of (2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid

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Technology Process of (2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid

There total 12 articles about (2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 852233-60-4
diethyl (2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4-[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioate

: 852233-70-6
(2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃;
DOI:10.1021/jm048984g

Reference yield:

: 607367-17-9
2-benzyl-malonic acid benzyl ester methyl ester

: 852233-70-6
(2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / H₂ / Pd/C / tetrahydrofuran / 20 °C

2: 33 percent / N-methylmorpholine; 1-hydroxybezotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

3: 89 percent / aq. NaOH / ethanol / 20 °C

4: 1-hydroxybenzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

5: hydroxylamine hydrochloride / methanol / 50 °C

6: triethylamine / CH₂Cl₂ / -10 - 20 °C

7: 78 percent / aq. NaOH / ethanol / 20 °C

With 4-methyl-morpholine; sodium hydroxide; hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm048984g

Reference yield:

: 852233-49-9
4-[(7-nitro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)methyl]benzonitrile

: 852233-70-6
(2S)-2-{[2-benzyl-3-oxo-3-({3-oxo-4[4-(5-oxo-4,5-dihydro-1,2,4-oxadiol-3-yl)benzyl]-3,4-dihydro-2H-1,4-benzoxazin-7-yl}amino)propanoyl]amino}pentanedioic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 73 percent / H₂ / Pd/C / dimethylformamide / 20 °C

2: 33 percent / N-methylmorpholine; 1-hydroxybezotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

3: 89 percent / aq. NaOH / ethanol / 20 °C

4: 1-hydroxybenzotriazole; N-methylmorpholine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide / dimethylformamide / pH 7

5: hydroxylamine hydrochloride / methanol / 50 °C

6: triethylamine / CH₂Cl₂ / -10 - 20 °C

7: 78 percent / aq. NaOH / ethanol / 20 °C

With 4-methyl-morpholine; sodium hydroxide; hydroxylamine hydrochloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm048984g