ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate
CAS No.:1314127-98-4
Molecular Formula:C₂₄H₂₆N₂O₅
Molecular Weight:422.481
Hs Code.:

Synonyms:ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate

Suppliers and Price of ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate

There total 5 articles about ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1119020-05-1
4-[(S)-1-(Tetrahydrofuran-2-yl)methoxy]benzoic acid

: 71056-58-1
5-amino-1-methyl-1H-indole-2-carboxylic acid ethyl ester

: 1314127-98-4
ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 87392-07-2
(S)-tetrahydro-2-furoic acid

: 1314127-98-4
ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 11 h / 22 - 75 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 10 °C

2.2: 2 - 4 °C

3.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 96 h / 20 - 25 °C

3.2: 2 h / 90 °C

3.3: Cooling with ice

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dmap / N,N-dimethyl-formamide / 24 h / 20 °C

With lithium aluminium tetrahydride; sulfuric acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; diethylazodicarboxylate; dmap; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1314127-98-4
ethyl 1-methyl-5-[({4-[(2S)-tetrahydrofuran-2-ylmethoxy]phenyl}carbonyl)amino]-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 96 h / 20 - 25 °C

1.2: 2 h / 90 °C

1.3: Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dmap / N,N-dimethyl-formamide / 24 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; diethylazodicarboxylate; dmap; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;