1-(7-cyclopropyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)ethanone

Base Information

• Chemical Name: 1-(7-cyclopropyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)ethanone
• CAS No.: 1242847-31-9
• Molecular Formula: C₂₈H₃₈N₄O₄S
• Molecular Weight: 526.7
• Mol file: 1242847-31-9.mol

Synonyms:1-(7-cyclopropyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)ethanone

Chemical Property of 1-(7-cyclopropyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(7-cyclopropyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)ethanone

There total 10 articles about 1-(7-cyclopropyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyclopropyl-2,7-diazaspiro[4.4]nonane (1242850-28-7) + 2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid (1242849-98-4) → 1-(7-cyclopropyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)ethanone (1242847-31-9)

Guidance literature:

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

1-(2-aminoethyl)pyrrole (29709-35-1) → 1-(7-cyclopropyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)ethanone (1242847-31-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2.1: polyphosphoric acid / 5 h / 90 °C

3.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C / 1500.15 Torr

4.1: triethylamine / dichloromethane / 20 °C

5.1: water; sodium hydroxide / tetrahydrofuran; methanol / 3 h / 20 °C

5.2: 0 °C

6.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

2-benzyl 2,7-diaza-spiro-[4.4]nonane (885275-27-4) → 1-(7-cyclopropyl-2,7-diazaspiro[4.4]nonan-2-yl)-2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)ethanone (1242847-31-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium cyanoborohydride; acetic acid / methanol / 4 h / Molecular sieve; Reflux

2: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 2250.23 Torr / Inert atmosphere

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; sodium cyanoborohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane;

upstream raw materials:

2-cyclopropyl-2,7-diazaspiro[4.4]nonane

2-(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)acetic acid

1-(2-aminoethyl)pyrrole

2-benzyl 2,7-diaza-spiro-[4.4]nonane