5'-O-(4,4'-dimethoxytrityl)inosine dialdehyde

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)inosine dialdehyde
• CAS No.: 119898-60-1
• Molecular Formula: C₃₁H₂₈N₄O₇
• Molecular Weight: 568.586
• Mol file: 119898-60-1.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)inosine dialdehyde

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)inosine dialdehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)inosine dialdehyde

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)inosine dialdehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

9-[(2R,3R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3,4-dihydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one (119898-59-8) → 5'-O-(4,4'-dimethoxytrityl)inosine dialdehyde (119898-60-1)

Guidance literature:

With sodium periodate; In water; acetone; for 24h; Ambient temperature; dark;

DOI:10.1016/S0040-4020(01)89829-X

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)inosine dialdehyde (119898-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / pyridine / 96 h / 15 °C

2: 91 percent / sodium periodate / acetone; H₂O / 24 h / Ambient temperature; dark

With sodium periodate; In pyridine; water; acetone;

DOI:10.1016/S0040-4020(01)89829-X

Reference yield:

Inosine (58-63-9) → 5'-O-(4,4'-dimethoxytrityl)inosine dialdehyde (119898-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / pyridine / 96 h / 15 °C

2: 91 percent / sodium periodate / acetone; H₂O / 24 h / Ambient temperature; dark

With sodium periodate; In pyridine; water; acetone;

DOI:10.1016/S0040-4020(01)89829-X

upstream raw materials:

9-[(2R,3R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-3,4-dihydroxytetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one

4,4'-dimethoxytrityl chloride

Inosine

Downstream raw materials:

5'-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

2',3'-dichloro-2',3'-dideoxy-5-O-(4,4'-dimethoxytrityl)-2',3'-secoinosine

5'-O-(4,4'-dimethoxytrityl)-2',3'-di-O-mesyl-2',3'-secoinosine