3-hydroxy-16-{2-[2-(4-methoxyphenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}estra-1,3,5⁽¹⁰⁾-trien-17-one

Base Information

• Chemical Name: 3-hydroxy-16-{2-[2-(4-methoxyphenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}estra-1,3,5⁽¹⁰⁾-trien-17-one
• CAS No.: 1620695-81-9
• Molecular Formula: C₂₈H₃₁N₃O₄S
• Molecular Weight: 505.638

Synonyms:3-hydroxy-16-{2-[2-(4-methoxyphenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}estra-1,3,5⁽¹⁰⁾-trien-17-one

Chemical Property of 3-hydroxy-16-{2-[2-(4-methoxyphenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}estra-1,3,5⁽¹⁰⁾-trien-17-one

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Technology Process of 3-hydroxy-16-{2-[2-(4-methoxyphenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}estra-1,3,5⁽¹⁰⁾-trien-17-one

There total 2 articles about 3-hydroxy-16-{2-[2-(4-methoxyphenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}estra-1,3,5⁽¹⁰⁾-trien-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

N(1)-(4-methoxyphenyl)-2-hydrazino-2-thioxoacetamide (127719-64-6) + 3-hydroxy-16-hydroxymethylideneestra-1,3,5(10)-trien-17-one (3460-92-2) → 3-hydroxy-16-{2-[2-(4-methoxyphenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}estra-1,3,5(10)-trien-17-one (1620695-81-9)

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 70 ℃; for 7h;

DOI:10.1007/s11172-013-0379-4

Reference yield:

Estrone (53-16-7) → 3-hydroxy-16-{2-[2-(4-methoxyphenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}estra-1,3,5(10)-trien-17-one (1620695-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate; pyridine / 18 h / 20 °C / Inert atmosphere

2: toluene-4-sulfonic acid / ethanol / 7 h / 70 °C

With pyridine; sodium methylate; toluene-4-sulfonic acid; In ethanol;

DOI:10.1007/s11172-013-0379-4

Reference yield: 72.0%

3-hydroxy-16-{2-[2-(4-methoxyphenylamino)-2-oxo-1-thioxoethyl]hydrazonomethyl}estra-1,3,5(10)-trien-17-one (1620695-81-9) → 5-[3-hydroxy-17-oxoestra-1,3,5(10)-trien-16-yl]-N-(4-methoxyphenyl)-1,3,4-thiadiazole-2-carboxamide (1620695-87-5)

Guidance literature:

With toluene-4-sulfonic acid; In 1,4-dioxane; for 8h; Reflux;

DOI:10.1007/s11172-013-0379-4

upstream raw materials:

Estrone

N⁽¹⁾-(4-methoxyphenyl)-2-hydrazino-2-thioxoacetamide

3-hydroxy-16-hydroxymethylideneestra-1,3,5⁽¹⁰⁾-trien-17-one

Downstream raw materials:

5-[3-hydroxy-17-oxoestra-1,3,5⁽¹⁰⁾-trien-16-yl]-N-(4-methoxyphenyl)-1,3,4-thiadiazole-2-carboxamide

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