Isobutyl bromoacetate

Base Information

• Chemical Name: Isobutyl bromoacetate
• CAS No.: 59956-48-8
• Molecular Formula: C6H11BrO2
• Molecular Weight: 195.056
• Mol file: 59956-48-8.mol

Synonyms:Isobutyl bromoacetate

Chemical Property of Isobutyl bromoacetate

Chemical Property:

• Refractive Index: 1.4530 (estimate)
• Boiling Point: 188°C (rough estimate)
• PSA: 26.30000
• Density: 1.3269
• LogP: 1.58050
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

IsobutylBromoacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Isobutyl Bromoacetate is a reactant for the synthesis of cephalosporins as potent activity against Gram-positive bacteria.

Technology Process of Isobutyl bromoacetate

There total 4 articles about Isobutyl bromoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methyl-propan-1-ol (78-83-1) + 2-Bromoacetyl bromide (598-21-0) → isobutyl 2-bromoacetate (59956-48-8)

Guidance literature:

In diethyl ether; at -23 - 25 ℃; for 4h;

DOI:10.1021/jm0302391

Reference yield:

2-bromoacetyl chloride (22118-09-8) + 2-methyl-propan-1-ol (78-83-1) → isobutyl 2-bromoacetate (59956-48-8)

Guidance literature:

at 25 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.ejmech.2021.113729

Reference yield:

2-methyl-propan-1-ol (78-83-1) + bromoacetic acid (79-08-3) → isobutyl 2-bromoacetate (59956-48-8)

Guidance literature:

With sulfuric acid;

upstream raw materials:

2-methyl-propan-1-ol

bromoacetic acid

2-Bromoacetyl bromide

2-bromoacetyl chloride

Downstream raw materials:

(3-oxo-cyclohex-1-enyl)-acetic acid isobutyl ester

4-(2-Isobutoxycarbonylmethoxy-3-methoxy-phenyl)-nicotinic acid 1,1-diethyl-propyl ester

i-butyl 3-pentafluorophenyl acrylate

i-butyl 3-p-chloro-tetrafluorophenyl acrylate