(R)-2-Methyl-7-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-phenyl-octan-3-one

Base Information

Chemical Name:(R)-2-Methyl-7-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-phenyl-octan-3-one
CAS No.:419572-81-9
Molecular Formula:C₃₁H₅₀O₂Si
Molecular Weight:482.822
Hs Code.:

Synonyms:(R)-2-Methyl-7-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-phenyl-octan-3-one

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Chemical Property of (R)-2-Methyl-7-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-phenyl-octan-3-one

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Technology Process of (R)-2-Methyl-7-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-phenyl-octan-3-one

There total 1 articles about (R)-2-Methyl-7-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-phenyl-octan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 770-85-4
2-methyl-2-phenylbutan-3-one

: 250384-86-2
Triethyl-[(3aR,4S,7aS)-1-((R)-3-iodo-1-methyl-propyl)-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-4-yloxy]-silane

: 419572-81-9
(R)-2-Methyl-7-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-phenyl-octan-3-one

Guidance literature:: 2-methyl-2-phenylbutan-3-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.25h;

Triethyl-[(3aR,4S,7aS)-1-((R)-3-iodo-1-methyl-propyl)-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-4-yloxy]-silane; In tetrahydrofuran; at -78 - 20 ℃; for 9h; Further stages.;
DOI:10.1021/jm010560o

Reference yield:

: 419572-81-9
(R)-2-Methyl-7-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-phenyl-octan-3-one

: (R)-7-((3aR,4S,7aS)-4-Hydroxy-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-methyl-2-phenyl-octan-3-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 8h;
DOI:10.1021/jm010560o

Reference yield:

: 419572-81-9
(R)-2-Methyl-7-((3aR,4S,7aS)-7a-methyl-4-triethylsilanyloxy-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-2-phenyl-octan-3-one

: (R)-7-{(3aS,7aS)-4-[2-[(3S,5R)-3,5-Dihydroxy-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl}-2-methyl-2-phenyl-octan-3-one O-methyl-oxime

Guidance literature:: Multi-step reaction with 5 steps

1.1: TBAF / tetrahydrofuran / 8 h / 20 °C

2.1: 14 mg / 4-methylmorpholine-N-oxide; tetrapropylammonium perruthenate / CH₂Cl₂ / 1 h

3.1: PhLi / tetrahydrofuran; cyclohexane; diethyl ether / 0.33 h / -78 °C

3.2: tetrahydrofuran; cyclohexane; diethyl ether / 4 h / -78 °C

4.1: pyridine / 36 h / 20 °C

5.1: 2.6 mg / TBAF; Et₃N / tetrahydrofuran / 24 h / 20 °C

With pyridine; tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; phenyllithium; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; 3.2: Horner-Wadsworth-Emmons coupling;
DOI:10.1021/jm010560o