[2-(2-benzyloxy-5-bromo-benzyloxymethoxy)-ethyl]-trimethyl-silane

Base Information

• Chemical Name: [2-(2-benzyloxy-5-bromo-benzyloxymethoxy)-ethyl]-trimethyl-silane
• CAS No.: 916441-57-1
• Molecular Formula: C₂₀H₂₇BrO₃Si
• Molecular Weight: 423.422
• Mol file: 916441-57-1.mol

Synonyms:[2-(2-benzyloxy-5-bromo-benzyloxymethoxy)-ethyl]-trimethyl-silane

Chemical Property of [2-(2-benzyloxy-5-bromo-benzyloxymethoxy)-ethyl]-trimethyl-silane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(2-benzyloxy-5-bromo-benzyloxymethoxy)-ethyl]-trimethyl-silane

There total 4 articles about [2-(2-benzyloxy-5-bromo-benzyloxymethoxy)-ethyl]-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

[2-(Benzyloxy)-5-bromophenyl]methanol (177759-46-5) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) → [2-(2-benzyloxy-5-bromo-benzyloxymethoxy)-ethyl]-trimethyl-silane (916441-57-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.tetlet.2006.09.059

Reference yield:

2-benzyloxy-5-bromobenzaldehyde (121124-94-5) → [2-(2-benzyloxy-5-bromo-benzyloxymethoxy)-ethyl]-trimethyl-silane (916441-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / tetrahydrofuran; methanol / 0 - 20 °C

2: 98 percent / DIEA / CH₂Cl₂

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.tetlet.2006.09.059

Reference yield:

benzyl bromide (100-39-0) → [2-(2-benzyloxy-5-bromo-benzyloxymethoxy)-ethyl]-trimethyl-silane (916441-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / 60 °C

2: NaBH₄ / tetrahydrofuran; methanol / 0 - 20 °C

3: 98 percent / DIEA / CH₂Cl₂

With sodium tetrahydroborate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; acetone;

DOI:10.1016/j.tetlet.2006.09.059

upstream raw materials:

[2-(Benzyloxy)-5-bromophenyl]methanol

(2-trimethylethylsilylethoxy)methyl chloride

2-benzyloxy-5-bromobenzaldehyde

benzyl bromide

Downstream raw materials:

2-methyl-2-[4-(pyridin-2-ylmethoxy)-3-(2-trimethylsilanyl-ethoxymethoxymethyl)-phenyl]-propionic acid methyl ester

2-[4-hydroxy-3-(2-trimethylsilanyl-ethoxymethoxymethyl)-phenyl]-2-methyl-propionic acid methyl ester

2-[3-hydroxymethyl-4-(pyridin-2-ylmethoxy)-phenyl]-2-methyl-propionic acid methyl ester

2-(4-benzyloxy-3-hydroxymethyl-phenyl)-2-methyl-propionic acid methyl ester